Targeting mitochondrial phenotypes for non-communicable diseases  

靶向线粒体表型防治非传染性疾病的运动干预策略(英文)

作　　者：Zhengtang Qi Shuzhe Ding 

机构地区：[1]The Key Laboratory of Adolescent Health Assessment and Exercise Intervention (East China Normal University),Ministry of Education [2]School of Physical Education and Health, East China Normal University

出　　处：《Journal of Sport and Health Science》2016年第2期155-158,共4页运动与健康科学（英文）

基　　金：supported by grants from the National Natural Science Foundation of China(No.31300977,31171142);Shanghai Pujiang Program(No.15PJC032);the Key Laboratory Construction Project of Adolescent Health Assessment and Exercise Intervention of Ministry of Education,China(No.40500-541235-14203/004)

摘　　要：The concept that ＂Exercise is Medicine＂ has been challenged by the rising prevalence of non-communicable chronic diseases （NCDs）. This is partly due to the fact that the underlying mechanisms of how exercise influences energy homeostasis and counteracts high-fat diets and physical inactivity is complex and remains relatively poorly understood on a molecular level. In addition to genetic polymorphisms in humans that lead to gross variations in responsiveness to exercise, adaptation in mitochondrial networks is central to physical activity, inactivity, and diet. To harness the benefits of exercise for NCDs, much work still needs to be done to improve health effectively on a societal level such as developing personalized exercise interventions aided by advances in high-throughput genomics, proteomics, and metabolomics. We propose that understanding the mitochondrial phenotype according to the molecular information of genotypes, lifestyles, and exercise responsiveness in individuals will optimize exercise effects for prevention of NCDs.慢性非传染性疾病发病率不断上升,对"运动即良医"的概念提出挑战,一定程度上是因为运动对能量平衡的影响机制及其与高脂膳食、久坐不动的交互作用非常复杂,且人们在分子水平上还知之甚少。另外,人类基因多态性导致机体对运动的反应存在极大变异性,其中,线粒体网络对运动、久坐、膳食的适应性变化十分关键。为更准确发挥运动对非传染性疾病的防治作用,需从多因素水平考虑如何有效提升人口健康水平,例如依靠高通量基因组学、蛋白质组学和代谢组学方法研发个性化运动干预方案。本文建议根据基因型和运动响应的分子信息、个体生活方式鉴定线粒体表型,从而优化运动对非传染性疾病的预防作用。

关 键 词：Energy metabolism EXERCISE MITOCHONDRIAL Non-communicable chronic diseases Physical activity Precision medicine 

分 类 号：G804.2[文化科学—运动人体科学]