男性不育患者中Y染色体微缺失与生殖激素水平的相关性分析  

Analysis of gonadal hormone level in male infertility patients of Y chromosome microdeletion

作　　者：武爽[1] 韩锐[1] 刘志娟[1] 刘翛然[1] 

机构地区：[1]新疆医科大学第一附属医院母胎医学中心,新疆乌鲁木齐830000

出　　处：《中国优生与遗传杂志》2016年第7期27-28,26,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的筛查严重少精子症及无精子症患者Y染色体AZF区域微缺失的发生情况,探讨Y染色体微缺失患者与生殖激素水平的关系。方法对138例男性不育患者(其中无精子症患者86例,少精子症患者52例)进行Y染色体无精子因子(azoospermia factor,AZF)微缺失分析,同时用化学发光法测定生殖激素水平。结果 138例患者中发生AZF微缺失患者7例,检出率为5.04%,其中严重少精子症3例,无精子症4例。7例AZF微缺失情况:AZFb区缺失3例;AZFb+c区缺失4例。Y染色体AZFb区缺失患者的卵泡刺激素(FSH)值(53.36±41.59)m IU/m L及AZFb+c区患者的卵泡刺激素(FSH)值(39.16±20.14)m IU/m L显著高于无Y染色体AZF区缺失患者(13.7±10.62)m IU/m L,Y染色体AZFb区缺失患者的促黄体生成素(LH)值(19.41±12.52)m IU/m L及AZFb+c区患者的促黄体生成素(LH)值(16.66±6.78)m IU/m L显著高于无Y染色体AZF区缺失患者(6.29±3.94)m IU/m L,Y染色体AZFb区缺失患者的睾酮(T)值(1.75±0.75)ng/m L及AZFb+c区患者的睾酮(T)值(3.80±1.99)ng/m L显著低于无Y染色体AZF区缺失患者(5.53±1.90)ng/m L,差异具有统计学意义(P<0.05)。结论在无精子症及严重少精子症患者中Y染色体微缺失以AZFb区与AZFc区缺失最为常见。Y染色体AZFb+c区缺失是与FSH、LH和睾酮水平变化密切相关。Objective：To screen for Y chromosome microdeletions in patients with severe oligospermia or azoospermia,and explore the levels of gonadal hormone about patients of Ychromosome microdeletion. Methods：Y chromosome microdeletions among 52 patients with severe oligospermia and 86 patients with azoospermia were analyzed,and the levels of gonadal hormone were detected by chemilu-minescent met-hod. Results：The rate of microdeletion was 5.04%（7 out of 138 patients）,of which 3 were severe oligospermia,4 were azoospermia. The deletion was on AZFb ＋ c in 4patients,AZFb in 3 patients,respectively.The level of FSH（53.36.± 41.59 m IU/m L）in the AZFb and the level of FSH（39.16.± 20.14 m IU/m L）in the AZFb＋c deletion group was significantly higher than that in the group without Y chromosome deletion（13.7 ± 10.62 m IU/m L）. The level of LH（19.41.±12.52 m IU/m L）in the AZFb and the level of LH（16.66.± 6.78 m IU/m L）in the AZFb＋c deletion group was significantly higher than that in the group without Y chromosome deletion（6.29 ± 3.94 m IU/m L）. The level of T（1.75.± 0.75ng/m L）in the AZFb and the level of T（3.80.± 1.99ng/m L）in the AZFb＋c deletion group was significantly lower than that in the group without Y chromosome deletion（5.53 ± 1.90ng/m L）（P 0.05）.Conclusion：The common microdeletion regions were AZFb and AZFc on Y chromosome in azoospermia or severe oligozoospermia.The level changing of FSH,LH and T are closely related with the missing of Y chromosome.

关 键 词：Y染色体微缺失 无精子症 严重少精子症 生殖激素 

分 类 号：R698.2[医药卫生—泌尿科学]