肿瘤细胞死亡受体的调控  

The Regulation of Death Receptors in Tumor Cells

作　　者：郝花花 孔庆宏[1] 王冠林[1] 张宽仁[1] 

机构地区：[1]昆明理工大学生命科学与技术学院,昆明650500

出　　处：《中国细胞生物学学报》2016年第7期864-872,共9页Chinese Journal of Cell Biology

基　　金：国家自然科学基金(批准号:81260351;81360162)资助的课题~~

摘　　要：肿瘤坏死因子相关凋亡诱导配体(tumor necrosis factor related apoptosis inducing ligand,TRAIL)只有与细胞膜上死亡受体结合才能促使癌细胞凋亡,一旦细胞膜上的死亡受体发生缺失或失去活性,将使癌细胞对TRAIL极为耐受。近年来,对死亡受体的研究发现,死亡受体异常表达可能是死亡受体在细胞膜上发生功能性缺失的最主要原因。该文主要探究肿瘤细胞中死亡受体在转录调控、翻译后修饰、转运和内化过程中的异常情况,期望为今后研发克服TRAIL耐受的联合药物及癌症治疗提供参考。Tumor necrosis factor related apoptosis inducing ligand （TRAIL） can induce tumor apoptosis only after binding to its cognate death receptors （DRs） on the plasma membrane. The loss of DRs on the surface of cancer cells will result in tumor resistance to TRAIL-induced apoptosis and cell death. Recent studies have demonstrated that abnormal expression of death receptors may be the primary cause of the loss of cell surface death receptors. This review highlights the abnormal situation of death receptors in tumor cells, including the regulatory roles of transcription, post-translation modifications, trafficking and internalization, are possible mechanisms for the loss of death receptors in cell surface. This review provides a further reference theoretical basis for the development of multiple drugs combination therapy to overcome TRAIL resistance and to improve cancer therapy.

关 键 词：死亡受体 转录 翻译后修饰 转运 内化 凋亡因子耐受 癌症治疗 

分 类 号：R730.2[医药卫生—肿瘤]