SCN9A基因rs10930210位点多态性与癫痫发生的相关性  

Explore the relationship between SCN9A gene polymorphism and epilepsy

作　　者：左松林[1] 李欣宇[1] 伍明刚 张昭[1] 王景涛[2] 朱金玲[3] 

机构地区：[1]佳木斯大学临床医学院,黑龙江佳木斯154007 [2]佳木斯大学科技处,黑龙江佳木斯154007 [3]佳木斯大学基础医学院,黑龙江佳木斯154007

出　　处：《中风与神经疾病杂志》2016年第8期708-710,共3页Journal of Apoplexy and Nervous Diseases

基　　金：2015年黑龙江省大学生创新创业训练计划指导项目资助(No.201510222043);佳木斯大学创新团队项目资助(No.CXTDPY-201602)

摘　　要：目的探讨SCN9A基因多态性与癫痫发生的相关性。方法搜集134例癫痫患者及正常对照组73例血样,提取全基因组DNA。聚合酶链反应-限制性片段长度多态(PCR-RFLP)、测序法检测rs10930210位点多态性,比较该位点基因型和等位基因频率的差异。结果 SCN9A基因rs10930210位点多态性在癫痫组与对照组间无显著差异(P>0.05)。结论 SCN9A基因rs10930210位点多态性与癫痫易感性无关。Objective Explore the relationship between SCN9A gene polymorphism and epilepsy. Methods Collectedperipheral blood on 73 cases of normal control and 134 cases of epilepsy patients, and extracted genomic DNA bykits. Polymerase chain reaction-restriction fragment length polymorphism （ PCR-RFLP） , sequencing detected rsl0930210polymorphism, comparing the genotypes and allele frequency differences. Results SCN9A gene rsl0930210 polymorphismloci no significant differences between the epilepsy group and control group （P 〉0. 05）. Conclusion rsl0930210 polymorphism of SCN9A gene were not associated with epilepsy.

关 键 词：癫痫 SCN9A 单核苷酸多态性 遗传易感性 

分 类 号：R742.1[医药卫生—神经病学与精神病学]