环状RNA与疾病关系的研究进展  

Research progress of the relationship between circular RNA and diseases

作　　者：陈冉冉[1] 付玉荣[1] 伊正君[1] 

机构地区：[1]潍坊医学院医学检验学系,山东潍坊261031

出　　处：《基础医学与临床》2016年第9期1295-1300,共6页Basic and Clinical Medicine

基　　金：国家自然科学基金(81470001)

摘　　要：环状RNA是最近发现的一类内源性非编码RNA,由内含子配对驱动的环化等模型产生,受相关调控因子调控。环状RNA的一个重要生物学功能是作为miRNA海绵,使miRNA水平在短时间内发生明显改变。环状RNA与疾病密切联系,是具有诊断和治疗潜力的分子。本文论述环状RNA的生物合成及调控、环状RNA的生物学功能以及环状RNA与疾病的关系。Circular RNA is a newly discovered endogenous non-coding RNA, which is generated by the model of intron-pairing-driven circularization and is regulated by the relevant regulatory factors. One of the important biologi- cal functions of circular RNA is as a miRNA sponge, which makes the level of miRNA changed significantly in a short time. The circular RNA is closely related to the disease, which is a potential molecule of diagnosis and treat- ment. This paper deals with the three aspects of the biosynthesis and regulation of circular RNA, the biological function of circular RNA and the relationship between circular RNA and diseases.

关 键 词：环状RNA 非编码RNA 内含子配对驱动的环化 miRNA海绵 

分 类 号：R363[医药卫生—病理学] Q522[医药卫生—基础医学]