Ent-kaurane and ent-abietane diterpenoids from Isodon phyllostachys  

作　　者：Jin Yang Yaqi An Haiyan Wu Miao Liu Weiguang Wang Xue Du Yan Li Jianxin Pu Handong Sun Jin Yang;Yaqi An;Haiyan Wu;Miao Liu;Weiguang Wang;Xue Du;Yan Li;Jianxin Pu;Handong Sun(State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China;University of Chinese Academy of Sciences, Beijing 100049, China)

机构地区：[1]State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China [2]University of Chinese Academy of Sciences, Beijing 100049, China

出　　处：《Science China Chemistry》2016年第9期1211-1215,共5页中国科学（化学英文版）

基　　金：supported by the NSFC-Joint Foundation of Yunnan Province (U1302223);the National Natural Science Foundation of China (21322204);the West Light Foundation of the Chinese Academy of Sciences (J-X Pu)

摘　　要：Four new diterpenoids, phyllostachysins I-L （1-4）, along with a known one, hebeiabinin B （5）, were isolated from the aerial parts oflsodonphyllostachys （I.phyllostachys）. Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines （HL-60, SMMC-7721, A-549, MCF-7 and SW-480）, and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.Four new diterpenoids, phyllostachysins I–L(1–4), along with a known one, hebeiabinin B(5), were isolated from the aerial parts of Isodon phyllostachys(I. phyllostachys). Compounds 1 and 2 feature an ent-kaurane backbone, and 3, 4 and 5 bear an ent-abietane skeleton. Their structures were elucidated by means of spectroscopic analysis. Compounds 3 and 4 exhibited significant cytotoxic activity against human tumor cell lines(HL-60, SMMC-7721, A-549, MCF-7 and SW-480), and strongly inhibited NO production in LPS-stimulated RAW264.7 cells.

关 键 词：lsodon phyllostachys DITERPENOID ENT-KAURANE ent-abietane 

分 类 号：O629[理学—有机化学] TQ460.1[理学—化学]