广西肝癌高发区黄曲霉毒素B1与乙肝病毒的协同致癌机制的研究进展  

Research progress of aflatoxin B1 and hepatitis B virus synergistic carcinogenesis mechanism in high incidence area of hepatocellular carcinoma in Guangxi

作　　者：陈可和[1] 陈甲信[1] 

机构地区：[1]广西壮族自治区人民医院化疗二区,南宁530021

出　　处：《中国临床新医学》2016年第8期759-762,共4页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：国家自然科学基金资助项目(编号:81360368)

摘　　要：黄曲霉毒素B1（AFB1）与乙肝病毒（HBV）是广西肝癌高发的主要危险因素,而且两者的协同诱导的肝癌比单因素HBV发生的肝癌高30~60倍,但目前对AFB1/HBV诱发肝癌的具体作用与分子机制尚未见报道,现将广西肝癌高发区发生的可能相关因素归纳总结,为肝癌的防治提供依据。Aflatoxin B1（ AFB1） and hepatitis B virus（ HBV） are the major high risk factors of hepatocellular carcinoma（ HCC） in Guangxi Zhuang Autonomous Region of China. The synergism of AFB1 and HBV inducing HCC is 30 ~ 60 times stronger than the induction of HCC by the single factor HBV. However,to date,the role and mechanisms of AFB1 / HBV-induced HCC have not been known clear yet. The possible related factors of the occurrence of HCC in the high incidence area of Guangxi are summarized in this paper to provide the basis for the prevention and treatment of HCC.

关 键 词：肝癌 黄曲霉毒素B1 乙肝病毒 信号通路 

分 类 号：R735.7[医药卫生—肿瘤]