盐酸氯卡色林的合成工艺研究  

Synthesis of Locaserin hydrochloride

作　　者：吴之波 张玉娟[1] 范文进[1] 陈国良[1] 

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016

出　　处：《精细化工中间体》2016年第4期27-31,35,共6页Fine Chemical Intermediates

摘　　要：以对氯苯乙酸(2)为起始原料,经酯化、胺解、还原、氯代、烷基化、手性拆分、成盐等7步反应合成了盐酸氯卡色林,总收率为19.1%,其结构经ESI-MS、1H NMR及13C NMR确证。Locascrin hydrochloride was synthesized at a yield of 19.1% using 4-chlorophenylacetic acid as the starting material through a series of reactions including esterifieation, amination, reduction, chlorination, alkylation, chiral separation and salination. The structure of Locaserin hydrochloride and some intermediates were confirmed by ESI-MS,^1H NMR and ^13C NMR.

关 键 词：对氯苯乙酸 盐酸氯卡色林 合成 

分 类 号：R914.5[医药卫生—药物化学]