EGCG开窗灌洗治疗颌骨牙源性角化囊性瘤的临床疗效  

Outcome of marsupialization with epigallocatechin-3-gallate in treatment of keratocystic odontogenic tumors

作　　者：杨银辉 袁荣涛[1] 孔丽[1] 王科[1] 贾暮云[1] 

机构地区：[1]青岛大学附属医院口腔颌面外科,山东青岛266003 [2]青岛市口腔医院口腔颌面外科,山东青岛266003

出　　处：《口腔医学》2016年第9期817-820,共4页Stomatology

基　　金：青岛市公共领域科技支撑计划项目[11-2-3-1-(20)-nsh]

摘　　要：目的 应用EGCG（表没食子儿茶素没食子酸酯,epigallocatechin-3-gallate,EGCG）开窗灌洗治疗颌骨牙源性角化囊性瘤,观察其临床疗效。方法 18例颌骨牙源性角化囊性瘤患者,行局部开窗,并制作引流口保持器,分为2组：8例应用EGCG溶液灌洗囊腔,10例应用生理盐水灌洗囊腔。术后定期复诊,每2个月行曲面体层片及CT检查,观察比较两组囊腔变化情况,囊腔长径小于2 cm时行二期手术刮除残余囊壁。结果 EGCG溶液灌洗病例,开窗灌洗6~10月后囊腔即缩小至长径小于2 cm,行二期刮除手术。生理盐水灌洗病例,需10~16月囊腔缩小至长径小于2 cm,可行二期刮除手术。EGCG灌洗病例的临床疗程较生理盐水灌洗组明显缩短,差异有统计学意义,P〈0.05。结论 EGCG开窗灌洗可明显缩短颌骨牙源性角化囊性瘤的治疗周期。Objective To evaluate the outcome of marsupialization with epigalloeatechin-3-gallate （EGCG） in treatment of kerato- cystic odontogenie tumors （KCOT）. Methods 18 patients with KCOT in jaw were treated with marsupialization. Obturators were used to keep drainage open. All cases were divided into two groups： the cavity was rinsed by EGCG solution in 8 cases and by normal saline （NS） in the other 10 cases. Panoramic radiographs and CT were taken every two months during follow-up. Volume of the cavity was e- valuated and curettage was given as the diameter of the cavity was less than 2 cm. Results The diameter of the cavity was less than 2 em in 6-10 months after marsupialization in the group with EGCG and curettage treatment was given to take off the left cyst wall. It took 10-16 months to take curettage in the group with NS. The duration of marsupialization with EGCG was significantly shorter than that with NS （P〈0.05）. Conclusion Marsupialization with EGCG is an effective method to treat KCOT and can obviously reduce the dura- tion of treatment.

关 键 词：牙源性角化囊性瘤 开窗灌洗 表没食子儿茶素没食子酸酯 

分 类 号：R739.82[医药卫生—肿瘤]