基因检测技术在主动脉夹层诊疗中的价值及展望  

The value and future of gene detecting technique applied in the diagnosis and treatment of aortic ;dissection

作　　者：李笑[1] 魏茂增 徐峰[1] 陈玉国[1] 

机构地区：[1]山东大学齐鲁医院急诊科胸痛中心山东大学急危重症医学研究所山东省卫生系统急危重症医学重点实验室教育部卫生部心血管重构与功能研究重点实验室,济南250012

出　　处：《中华检验医学杂志》2016年第9期670-673,共4页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金（81571934,81570401,81300103）;泰山学者建设工程专项经费（ts20130911）;高等学校博士学科点专项科研基金（20130131110048）;山东省科技发展计划（2014GSF118111）;山东省科技惠民计划（2014kjhm0102）;山东大学齐鲁医院杰出青年人才基金项目

摘　　要：主动脉夹层（ AD）是一种心血管系统急危重症，现已被证实与基因突变存在密切关系。近几十年来，人们通过各种研究方法发现了大量AD的易感基因。通过基因检测技术，利用AD易感基因来指导疾病的预防、诊断、治疗，让人们在降低AD的发病率、死亡率方面看到了新的希望。现阶段，限于基因检测技术以及AD易感基因特异性、敏感性方面的不足，基因检测技术尚未广泛用于AD的诊疗过程中。但相信随着医学的发展，基因检测技术定能成为AD诊疗过程中的重要工具。Aortic Dissection is a kind of acute, severe disease of cardiovascular system, and has been confirmed to be closely connected with gene mutation.In recent decades, people have found a large number of susceptibility genes of AD through various methods.Utilizing AD susceptibility genes, tested by genetic technology to assist the prevention, diagnosis and treatment of AD brings new hopes in reducing the incidence and mortality of this disease.Up to now, the shortcomings of gene detecting technique and the specificity, sensitivity of AD susceptibility genes have still limited the use of gene detecting technique in AD management.Of course, with the development of medicine, gene detecting technique must become an important tool in AD diagnosis and treatment.

关 键 词：动脉瘤 夹层 基因检测 疾病遗传易感性 

分 类 号：R543.1[医药卫生—心血管疾病] R440[医药卫生—内科学]