Regional brain structural abnormality in ischemic stroke patients:a voxel-based morphometry study  

作　　者：Ping Wu Yu-mei Zhou Fang Zeng Zheng-jie Li Lu Luo Yong-xin Li Wei Fan Li-hua Qiu Wei Qin Lin Chen Lin Bai Juan Nie San Zhang Yan Xiong Yu Bai Can-xin Yin Fan-rong Liang 

机构地区：[1]Acupuncture and Tuina School/Third Teaching Hospital,Chengdu University of Traditional Chinese Medicine [2]China Academy of Chinese Medical Sciences,World Federation of Acupuncture-Moxibustion Societies [3]Institute of Clinical Anatomy,School of Basic Medical Sciences,Southern Medical University [4]Radiology Department,West China Hospital of Sichuan University [5]Life Sciences Research Center,School of Life Sciences and Technology,Xidian University

出　　处：《Neural Regeneration Research》2016年第9期1424-1430,共7页中国神经再生研究（英文版）

基　　金：financially supported by the National Program on Key Basic Research Project of China(973 Program);No.2012CB518501;the National Natural Science Foundation of China,No.81072864

摘　　要：Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.Our previous study used regional homogeneity analysis and found that activity in some brain areas of patients with ischemic stroke changed significantly. In the current study, we examined structural changes in these brain regions by taking structural magnetic resonance imaging scans of 11 ischemic stroke patients and 15 healthy participants, and analyzing the data using voxel-based morphometry. Compared with healthy participants, patients exhibited higher gray matter density in the left inferior occipital gyrus and right anterior white matter tract. In contrast, gray matter density in the right cerebellum, left precentral gyrus, right middle frontal gyrus, and left middle temporal gyrus was less in ischemic stroke patients. The changes of gray matter density in the middle frontal gyrus were negatively associated with the clin- ical rating scales of the Fugl-Meyer Motor Assessment （r = -0.609, P = 0.047） and the left middle temporal gyrus was negatively correlated with the clinical rating scales of the nervous functional deficiency scale （r = -0.737, P = 0.010）. Our findings call objectively identify the functional abnormality in some brain regions of ischemic stroke patients.

关 键 词：nerve regeneration ischemic stroke brain structure abnormality Junctional magnetic resonance imaging gray matter density voxel-based morphometry Fugl-Meyer Motor Assessment nervous fi^nctional deficiency scale functional deficiency NEUROPLASTICITY neuralreorganization neural regeneration 

分 类 号：R743.3[医药卫生—神经病学与精神病学]