垂体腺瘤致视力障碍患者视觉皮层及相关功能网络静息状态局部一致性的改变  

Changes of regional homogeneity in vision-related resting-state network of pituitary adenoma patients with visual damage

作　　者：钱海燕[1] 王兴朝[1] 刘丕楠[1] 

机构地区：[1]首都医科大学附属北京天坛医院神经外科,北京100050

出　　处：《山东大学学报（医学版）》2016年第10期60-65,共6页Journal of Shandong University:Health Sciences

摘　　要：目的探索垂体腺瘤致视力障碍患者视觉皮层及相关功能网络的神经可塑性。方法以25例垂体腺瘤致视力障碍患者及25例与之年龄、性别相匹配矫正后视力正常患者为研究对象,进行神经眼科学检查及结构态和静息态功能核磁扫描。分别对两组受试者静息状态视觉皮层及相关功能网络进行局部一致性分析后,再采用双样本t检验进行统计学分析。结果与正常人群受试者相比,垂体瘤所致视力障碍患者组双侧V1、V2、V3、枕叶外侧皮层,梭状回、MT+以及丘脑局部一致性显著降低,而双侧楔前回、前额叶、扣带回后部皮层、岛叶、缘上回、辅助运动区局部一致性升高。结论垂体腺瘤致前视路功能障碍可引起患者视觉皮层内部脑区神经活动减弱,视觉皮层外默认网络及显著网络内重要脑区神经活动增强。Objective To explore the neural plasticity of vision-related network in pituitary adenoma patients with visual damage. Methods A total of 25 pituitary adenoma patients with visual damage（ PAPVD） and 25 age- and sexmatched corrected-normal-sighted healthy controls（ HCs） were recruited and underwent a complete neuro-ophthalmologic evaluation as well as an MRI protocol,including structural and resting-state f MRI（ RS-f MRI） sequences. Regional homogeneity（ Re Ho） of the vision-related resting-state network were evaluated. Two sample t-test was conducted to identify the changes between the two groups. Results Compared to HCs,PAPVDs showed a reduced Re Ho in bilateral V1,V2,V3,lateral occipital complex（ LOC）,fusiform,MT ＋,thalamus,and an increased Re Ho in precuneus gyrus,prefrontal cortex,posterior cingulate cortex（ PCC）,insular,supramarginal gyrus（ SMG）,and upplementary motor area（ SMA）. Conclusions Visual damage caused by pituitary adenoma can lead to decreased neural activity within the visual cortex,and increased neural activity beyond the visual cortex especially in core nodes of default mode network（ DMN） and salience network（ SN）.

关 键 词：视觉障碍 静息态核磁共振 默认网络 显著网络 神经可塑性 

分 类 号：R739[医药卫生—肿瘤]