遗传印记基因PEG10在结肠癌中的表达及意义  

Significance and expression of genetic imprinted gene PEG10 in colon cancer

作　　者：谢军培[1] 张玉琴[1] 林园园[1] 朱小三[1] 沈许德[1] 傅育卡[1] 桑巧芳[1] 戴益琛[1] 

机构地区：[1]中国人民解放军第一七四医院消化内科,福建厦门361003

出　　处：《胃肠病学和肝病学杂志》2016年第10期1168-1170,共3页Chinese Journal of Gastroenterology and Hepatology

基　　金：厦门市科技计划项目[遗传印记基因PEG10在大肠癌及癌前病变中的印记缺失研究(2014S0479)]

摘　　要：目的研究遗传印记基因PEG10在结肠癌、癌旁组织、正常结肠组织中的表达及意义。方法收集中国人民解放军第一七四医院2015年1月-2015年9月40例结肠癌、癌旁组织,20例正常结肠组织标本,通过免疫组织化学及蛋白印迹法检测PEG10的细胞定位及其表达差异。结果 PEG10细胞主要分布于细胞质,在结肠癌中呈过表达,其表达明显高于癌旁组织、正常结肠组织,差异有统计学意义(P<0.01)。结论 PEG10可能参与结肠癌发生、发展,但其具体作用机制仍需进一步探讨。Objective To investigate the expression and significance of genetic imprinted gene PEG10 in colon canc- er, adjacent mucosa, normal colon tissue. Methods Forty cases of surgically specimens and 20 cases of normal tissue specimens were collected. PEG10 expression in colon cancer, normal colon tissue was determined by immunohistocbem- istry （IHC）. Differential expression of PEG10 protein in colon cancer, adjacent cancer, normal colon tissue was ob- served by Western blotting. Results PEG10 cells were located in the cytoplasm of colon cancer cell. PEG10 was over- expression in colon cancer, and was absent in normal colon tissue. The significant difference was observed in PEG10 positivity rate among adjacent mucosa, normal colon tissue （P 〈 0.01 ）. Conclusion PEG10 may be involved in the development of colon cancer. However, the mechanisms of PEG10 in colon cancer need further studied.

关 键 词：印记基因 PEG10 结肠癌 

分 类 号：R735.35[医药卫生—肿瘤]