缺氧诱导因子1α和转化生长因子β1在子宫内膜癌中的表达及其临床意义  

Expression of hypoxia inducible factor-1αand transforming growth factor-β1 in endometrial carcinoma and their clinical significances

作　　者：杨军文[1] 倪观太[1] 

机构地区：[1]皖南医学院弋矶山医院妇产科,安徽省芜湖市241001

出　　处：《中国综合临床》2016年第9期830-833,共4页Clinical Medicine of China

摘　　要：目的：检测子宫内膜癌组织中缺氧诱导因子1α（ HIF-1α）和转化生长因子β1（ TGF-β1）的表达并探讨其临床意义。方法选取2012年2月至2015年2月手术治疗54例子宫内膜癌及20例正常子宫内膜，应用免疫组化法检测HIF-1α和TGF-β1的表达，并分析其与临床病理及预后的关系。结果子宫内膜癌组织中HIF-1α和TGF-β1表达分别为59．26％（32／54）、64．81％（35／54），二者显著高于正常子宫内膜癌组织（1／20、0）（χ2值分别为17．390、24．596，P均＜0．01）；HIF-1α表达与子宫内膜癌FIGO分期（χ2＝6．712，P＝0．010）、脉管浸润（χ2＝4．804，P＝0．036）、浸润深度（χ2＝6．484，P＝0．011）及腹膜后淋巴结转移（χ2＝5．732， P＝0．017）均相关；TGF-β1表达与子宫内膜癌 FIGO 分期（χ2＝4．878， P＝0．027）、浸润深度（χ2＝4．060，P＝0．044）及腹膜后淋巴结转移（χ2＝5．211，P＝0．022）；在子宫内膜癌组织HIF-1α和TGF-β1表达呈正相关（ r＝0．705，P＝0．000）。结论 HIF-1α和TGF-β1增高可能共同参与了宫内膜癌发生及浸润转移，并有可能成为其治疗的靶点。Objective To examine the expressions of hypoxia inducible factor-1α（ HIF-1α） and trans-forming growth factor-β1 （ TGFβ1） in patients with endometrial carcinoma,to investigate their clinical signifi-cances. Methods Fifty-four patients with endometrial carcinoma and 20 patients with normal endometrium were selected in Yijishan Hospital of Wannan Medical College from2012 to 2015. Expression of HIF-1αand TGF-β1 were detected by immunohistochemical method respectively,the correlations between HIF-1α,TGF-β1 and clinic pathologic characteristics and prognostic significance were analyzed. Results The positive expression rates of HIF-1αand TGF-β1 were 59. 26%（ 32/54） and 64. 81%（ 35/54） in endometrial carcinoma respectively,signifi-cantly higher than of expression of patients with normal endometrium （ 5. 00%（ 1/20 ） , 0 （ 0 ）;χ2 =17. 390, 24. 596;P〈0. 01）. The expressions of HIF-1α were correlated with FIGO stage（χ2=6. 712,P=0. 010）,tumor thrombus in pulse tube（χ2=4. 804,P=0. 036）,deep myometrial invasion（χ2=6. 484,P=0. 011）,and lymph node metastasis（χ2 = 5. 732, P= 0. 017 ） . The expression of TGF-β1 were correlated with FIGO stage （χ2=4. 878,P=0. 027） ,deep myometrial invasion（χ2=4. 060,P=0. 044） and lymph node metastasis（χ2=5. 211, P=0. 022）. Expression of HIF-1αwas positively correlated with expression of TGF-β1（r=0. 705,P=0. 000） . Conclusion Increased expressions of HIF-1αand TGF-β1 are all involved in carcinogenesis,progression and metastasis of endometrial carcinoma,which may be considered as a target in endometrial carcinoma therapy.

关 键 词：子宫内膜癌 缺氧诱导因子1Α 转化生长因子Β1 Hypoxia INDUCIBLE factor-1α TRANSFORMING growth factor-β1 

分 类 号：R575.2[医药卫生—消化系统]