膳食纤维摄入与前列腺癌发生风险关系的Meta 分析  

Dietary fiber intake and risk of prostate cancer：a Meta-analysis

作　　者：刘维帅[1,3] 曾亚奇[2,3] 邵月娟[1,3] 王昆[1,3] 

机构地区：[1]天津医科大学肿瘤医院疼痛治疗科,300060 [2]天津医科大学肿瘤医院营养科,300060 [3]国家肿瘤临床医学研究中心 天津市肿瘤防治重点实验室

出　　处：《国际肿瘤学杂志》2016年第10期758-764,共7页Journal of International Oncology

基　　金：国家自然科学基金（81201065）;天津医科大学肿瘤医院院级科研种子基金（1419）

摘　　要：目的：探讨膳食纤维摄入与前列腺癌发生风险之间的关系。方法系统检索 PubMed、EMBase、Cochrane library、中国知网数据库（CNKI）、万方数据库、中国生物医学文献数据库（CBM）中符合要求的文献，采用 Meta 分析方法，以随机模型和95％CI 为效应量分析膳食纤维摄入量与前列腺癌发生之间的关系。另外，采用随机剂量反应模型进行定量分析。结果共纳入10篇文献，包括5篇队列研究和5篇病例对照研究。与膳食纤维最低摄入组相比，膳食纤维最高摄入组前列腺癌发生的风险显著降低了13％（RR ＝0．87，95％CI 为0．77～0．99，Z ＝2．10，P ＝0．035）。亚组分析显示，可溶性膳食纤维（RR ＝0．78，95％CI 为0．64～0．95，Z ＝2．45，P ＝0．014）及不可溶性膳食纤维（RR ＝0．65，95％CI 为0．45～0．88，Z ＝2．79，P ＝0．005）的摄入均与前列腺癌的发生呈负相关，但谷类、水果以及蔬菜类纤维的摄入与前列腺发生没有明显关系。剂量反应曲线结果显示膳食纤维的摄入量与前列腺癌的发生风险没有明显关联（RR ＝0．996，95％CI 为0．989～1．002）。敏感性分析显示总体研究结果比较稳定，单个研究不会对总体结果造成显著影响。结论膳食纤维的摄入与前列腺癌发生风险呈负相关，适当增加膳食纤维的摄入可能有利于前列腺癌的预防，但尚需进一步开展前瞻性研究验证本研究结果。Objective To determine the relationship between dietary fiber intake and risk of prostate cancer.Methods Electronic databases including PubMed,EMBase,Cochrane library,China National Knowledge Internet （CNKI）,Wanfang and CBMwere searched to find eligible studies.Random-effects relative risk （RR）and its corresponding 95%CI were used.Besides,random-effects dose-response analyses were also performed to clarify the dose-response relations.Results Ten studies,including five cohort studies and five case-control studies,were eligible and included in this Meta-analysis.The pooled RR of prostate cancer for the highest compared with the lowest dietary fiber intake was 0.87 （95%CI：0.77-0.99,Z =2.10,P =0.035）. In addition,pooled estimated data showed that risk of prostate cancer was significantly associated with soluble fiber （RR =0.78,95%CI：0.64-0.95,Z =2.45,P =0.014）and insoluble fiber （RR =0.65,95%CI：0.45-0.88,Z =2.79,P =0.005）,but not with fruit,vegetable and cereal fiber intake.However,in dose-response analysis,no significant association was reported （RR =0.996,95%CI：0.989-1.002）.Sensitivity analysis showed that the overall results were relatively stable,and omission of any single study had little effect on the combined results.Conclusion Dietary fiber intake is negative related to the risk of prostate cancer. Intake of dietary fiber is recommended to prevent prostate cancer.Considering the limitations of the included studies,more well-designed prospective studies will be needed to confirm our findings.

关 键 词：膳食纤维 前列腺肿瘤 META 分析 

分 类 号：R737.25[医药卫生—肿瘤]