p53与消化系统恶性肿瘤的研究进展  

Roles of p53 in the interaction with digestive malignant tumors

作　　者：王鹏[1] 王征[1] 周志祥[1] 

机构地区：[1]中国医学科学院肿瘤医院结直肠外科,北京100021

出　　处：《实用肿瘤学杂志》2016年第5期468-472,共5页Practical Oncology Journal

摘　　要：p53作为目前广泛研究的肿瘤抑制基因,在调节细胞周期、修复损伤DNA、清除自由基、调控免疫反应等过程中均起重要作用。目前研究发现,p53突变与50%以上消化系统恶性肿瘤的发生、发展、浸润和转移等生物学行为密切相关。鉴于目前的研究发现,本文对p53的生物学特性、p53与消化系统恶性肿瘤的关系及基因治疗进行综述,希望为消化系统恶性肿瘤的发病机制、诊治及预后提供参考。p53,the widely studied tumor suppressor gene ,plays a key role in regulating cell cycle ,repai-ring DNA damages , eliminating free radicals and regulating immune responses and so on .The recent studies showed that p53 mutation was in close biological connections with the occurrence , development , infiltration and metastasis in over 50 percent digestive systemic malignant tumors .In view of the current researches ,we review the biological features of p53,the relationship between p53 and digestive systemic malignant tumors ,and gene therapy of p53 to provide references for the pathogenesis ,diagnosis,treatment and prognosis of digestive systemic malig-nant tumors in this paper .

关 键 词：P53 突变 消化系统恶性肿瘤 基因治疗 

分 类 号：R735[医药卫生—肿瘤]