木贼配方颗粒喷雾干燥工艺优化  

Optimization of Spray Drying Process of Equiseti Hiemalis Herba Dispensing Granule

作　　者：邵杰[1] 张爱丽[2] 施静[1] 王振中[1] 萧伟[1] 

机构地区：[1]江苏康缘药业股份有限公司,江苏连云港222001 [2]江苏联合职业技术学院连云港中医药分院,江苏连云港222007

出　　处：《中国实验方剂学杂志》2016年第21期19-22,共4页Chinese Journal of Experimental Traditional Medical Formulae

基　　金：国家"重大新药创制"科技重大专项(2013ZX09402203)

摘　　要：目的:优选木贼配方颗粒的喷雾干燥工艺条件,制备合格的中间体,以利于后续干法制粒工序的开展。方法:以出粉率和粒径分布为指标,通过单因素试验筛选辅料种类;利用Minitab 16软件中的Plackett-Burman设计,以出粉率为指标,筛选影响喷雾干燥的3个主要影响因素(进风温度、固含比、进料速度),并确定非主要影响因素的水平。以山柰素转移率、细粉吸湿率和出粉率为指标,利用Box-Behnken优选工艺参数。结果:最佳喷雾干燥工艺条件为3%微粉硅胶加入固含量20%的木贼浸膏中,料液温度65℃,进风温度151℃,进风量4 m3·min^(-1),进料速度33 m L·min^(-1)。山柰素转移率94.2%,喷干粉吸湿率20.6%,出粉率85.0%。结论:优选的喷雾干燥工艺稳定可行,为木贼配方颗粒的大生产提供参考。Objective： To optimize spray drying process of Equiseti Hiemalis Herba dispensing granule for preparing qualified intermediates. Method： Taking flour yield and particle size distribution as indicators to screen the auxiliary materials category. This research was studied based on the Plackett-Burman design in Minitab16 software,taking flour yield as indicator,screening out three major factors（ inlet air temperature,solid content ratio and feed rate） influenced the spray drying process,and determining the level of non-main factors. On this basis,with transfer rate of kaempferol,moisture absorption rate of fine powder and flour yield as indexes,BoxBehnken was employed to optimize process parameters. Result： Optimum spray drying process conditions were obtained as follows： adding 3% micro-silica into Equiseti Hiemalis Herba extract with solid content ratio of 20%,temperature of feed liquid 65 ℃,inlet air temperature at 151 ℃,intake air volume of 4 m3·min^（-1）,feed rate of33 m L·min^（-1）. Under these conditions,transfer rate of kaempferol was 94. 2%,moisture absorption rate of fine powder was 20. 6% and flour yield was 85. 0%. Conclusion： This optimized spray drying process is stable and feasible,which can provide basis for mass production of Equiseti Hiemalis Herba dispensing granule.

关 键 词：木贼 配方颗粒 喷雾干燥 出粉率 山柰素 吸湿率 

分 类 号：R283.6[医药卫生—中药学] R284.1[医药卫生—中医学]