借鉴基因芯片技术,以性味药理学理论为依据,探讨薏苡仁不同拆分组分对脾虚水湿不化模型大鼠oxidoreductase activity的影响  

Oxidoreductase Activity on Spleen Deficiency and Dampness Retention Rats Treated by Separated Components of Coix Seed Based on Genomic Technologies Taste of Pharmacology Theory

作　　者：韩晓春[1] 季旭明[1] 王彦芳[1] 庞张祥 王海瑞[1] 王世军[1] 

机构地区：[1]山东中医药大学中医学院(基础医学院),山东济南250355

出　　处：《中华中医药学刊》2016年第11期2595-2598,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)项目(2013CB531803);山东省中医药科技发展计划项目(2015-008)

摘　　要：目的:借鉴基因芯片技术,探讨薏苡仁拆分组分健脾渗湿作用时对能量代谢的影响。方法:根据本项目组建立的方法对薏苡仁组分拆分和动物模型建立,以中焦空肠的基因变化为研究指标,探讨各组分对空肠oxidoreductase activity的影响。结果:模型动物存在明显的能量代谢障碍,薏苡仁各组分均可以改善这种障碍,但其作用靶点可能并不一致。结论:建议在使用薏苡仁治疗脾虚疾病时,以麸炒方式炮制,以提高疗效。Objective：To evaluate the energy metabolism of spleen deficiency and dampness retention rats treated by components of coix seed. Methods：Establish the rat model and split the coix seed. Test the gene change in jejunum of middle Jiao and evaluate the effects of jejunum oxidoreductase activity. Results：Model animals have obvious disturbance of energy metabolism. Each coix seed components can improve the disorder hut the target may be not consistent. Conchs. sion：It is recommended to use bran fried coix seed to treat spleen deficiency disease.

关 键 词：薏苡仁 性味 能量代谢 脾虚水湿 

分 类 号：R-332[医药卫生]