复方D-核糖对小鼠抗疲劳作用的研究  

Study on anti- fatigue effect of compound D- ribose on mice

作　　者：袁保辉 刘桂芹[1] 刘敏[1] 李大成[1] 韩军[1] 王正平[1] 

机构地区：[1]聊城大学临床营养研究中心,山东聊城252000

出　　处：《食品工业科技》2016年第22期349-353,共5页Science and Technology of Food Industry

基　　金：聊城市科技计划项目(2013 GJH15);聊城大学科技项目(318011405);聊城大学大学生科技文化创新基金项目(26312158809)

摘　　要：本实验以80只雄性小鼠为实验动物,通过连续四周的灌胃实验研究了核糖复方对疲劳小鼠生理功能的影响。实验小鼠被随机分为生理盐水组、核糖组、人参玛咖组以及核糖复方组。在各组给予相应的干预措施下,测定了小鼠末次运动0 h和24 h后的血清乳酸含量、尿素氮含量及肝糖原含量的变化。结果表明,与对照组比较,D-核糖及核糖复方在急性疲劳期间可以显著延长小鼠的游泳时间(p<0.05);长期疲劳中,核糖复方组可以增加小鼠的肝糖原(p<0.01),降低血清乳酸(p<0.01)及尿素氮(p<0.05)含量。实验结果证实核糖复方总体效果优于人参玛咖及核糖单方的抗疲劳功效;对急性疲劳中的小鼠,D-核糖及其核糖复方均具有明显的抗疲劳作用;对长期疲劳的小鼠,D-核糖没有表现出明显的抗疲劳作用。In this study,80 male mice were examined over a 4-week period of daily gavage feeding to study the effects of D-ribose compounds on the ability of mice to withstand fatigue.The mice were randomly divided into the saline control group,the ribose group,the ginseng and maca group,and the ribose compounds group.Each group was given the appropriate intervening measures,and the mice were evaluated at 0 hours and 24 hours after their movements to measure changes in lactic acid, urea nitrogen,and liver glycogen.The results showed that D-ribose and ribose compounds, during periods of extreme fatigue, could significantly extend the swimming time of mice （ p 〈 0.05 ）, and that ribose compounds could increase liver glycogen （ p 〈 0.01 ） and decrease lactic acid （ p 〈 0.01 ） and urea nitrogen concentration（p 〈 0.05）.The results also confirmed that the compound d-ribose was better than the D-ribose or the ginseng and maca group in general terms and during period of extreme fatigue in mice, D-ribose and ribose compounded clearly possess anti-fatigue properties.With regards to long-term fatigue, D-ribose did not show clear anti-fatigue uses.

关 键 词：小鼠 抗疲劳 D-核糖 人参 玛咖 D-核糖复方 

分 类 号：TS201.4[轻工技术与工程—食品科学]