高压静电喷雾法制备海藻酸钠微囊的工艺优选  

OPTIMIZATION ON THE PREPARATION OF SODIUM ALGINATE-MICROCAPSULES BY USING ELECTROSTATIC SPRAY METHOD

作　　者：叶财敏 陈娟娟[1] 梁翠薇 吴修团 李文良[1] 谢柳蓉 廖红兵[1] Ye Caimin Chen Juanjuan Liang Cuiwei Wu Xiutuan Li Wenliang Xie Liurong Liao Hongbing(Department of Prosthodontics, College of Stomatology Guangxi Medical University, Nanning 530021,China)

机构地区：[1]广西医科大学附属口腔医院修复科,南宁530021

出　　处：《广西医科大学学报》2016年第3期408-411,共4页Journal of Guangxi Medical University

基　　金：国家自然科学基金资助项目(No.81260170)

摘　　要：目的：探索高压静电喷雾技术制备特定粒径分布范围海藻酸钠微囊的工艺参数。方法：通过正交试验对100～200μm海藻酸钠微囊粒径的影响因素进行显著性分析,使用高压静电喷雾装置制备海藻酸钠微囊,样品使用激光测粒仪测量微囊的粒径分布,以100～200μm微囊的百分比作为指标,同时使用光学显微镜自带的测量系统测量微囊的粒径。结果：频率、气压、液距、Tween20含量、电压和温度等6个因素中,Tween20含量对海藻酸钠微囊粒径有显著影响,其余因素影响不显著。海藻酸钠微囊的粒径分布集中于100～200μm区间段的优化参数为Tween20含量0、电压2 000V、频率1 500Hz、气压50kPa、液距7cm和温度30℃。结论：通过对参数的优化设定,可获得单分散性好的海藻酸钠微囊。Objective：To investigate the technical parameters of making specific size of sodium alginate-microcapsule by using electrostatic spray method.Methods：The orthogonal tests were utilized to get the optimal parameters for the sodium alginate-microcapsule within the particle diameter within 100-200μm.Electrostatic spray method was used to prepare the sodium alginate-microcapsule,and its diameter was measured with laser particle sizer and microscope.Results：Among all related factors,the content of Tween 20 had significant effect on the diameter of sodium alginate-microcapsule.The optimal technological parameters for sodium alginate-microcapsule preparation included 0% Tween 20,2 000 Vvoltage,1 500 Hz frequency,50 kPa pressure,7cm liquid pitch,and 30℃ temperature.Conclusion：With the optimization of parameters,sodium alginate-microcapsule with good dispersion can be achieved.

关 键 词：微胶囊 海藻酸钠 静电喷 

分 类 号：R783.2[医药卫生—口腔医学]