营养对衰老及年龄相关疾病的影响  

Effect of nutrition on aging and age-related diseases

作　　者：何志超[1] 蒋伟文[1] 

机构地区：[1]上海交通大学医学院附属第九人民医院口腔黏膜科.上海市口腔医学研究所.上海市口腔医学重点实验室,主任医师硕士生上海200125

出　　处：《中华老年口腔医学杂志》2016年第5期312-316,共5页Chinese Journal of Geriatric Dentistry

基　　金：国家自然基金面上项目(项目编号:30872887);上海市自然科学基金项目(项目编号:15ZR1424700);国家临床重点专科建设项目(项目编号:[2013]544-03)

摘　　要：衰老是人体组织器官功能随年龄增长而减退的不可逆现象。营养对衰老和年龄相关疾病有显著的影响。宏量营养素比例的改变和一些微量元素与营养补充剂可延缓衰老和年龄相关疾病的发生。对营养因素影响衰老主要集中在IIS、TOR、Sirtuin和AMPK信号通路。本文就关于营养素摄入与人体衰老和年龄相关疾病的研究做一总结和综述,探讨通过营养干预措施延缓衰老和年龄相关疾病发生的可能性。Aging is an irreversible phenomenon of the degeneration of human somatic tissue and organs with age.Nutrition has a significant impact on aging and age-related diseases.Changes of the proportion of macronutrients,and some trace elements and nutritional supplements can delay the occurrence of aging and age related diseases.The mechanism of nutrition and aging was addressed on signaling pathway of IIS,TOR,Sirtuin and AMPK.This study presents a summary and review on nutrient intake and human aging and age-related disease research,and discusses the possibility of delaying aging and age-related diseases through nutrition intervention.

关 键 词：营养 营养素 衰老 年龄相关疾病 

分 类 号：R592[医药卫生—老年医学]