牛蒡、桑叶和灵芝改善糖尿病作用研究  

Hypoglycemic effect of the compound of burdock,mulberry leaf and ganoderma lucidum on diabetic rats

作　　者：邢梅梅[1] 朱晓娣[1] 邵欣[1] 康文艺[1,2] 孙慧玲[1,2] 郭秀春[1,2] 

机构地区：[1]河南大学中药研究所,河南开封475004 [2]开封市保健食品功效成分研究重点实验室,河南开封475004

出　　处：《食品工业科技》2016年第23期338-342,共5页Science and Technology of Food Industry

基　　金：国家教育部大学生创新创业计划(201510475073);河南省产学研项目(152107000051);河南省高校科技创新团队(16IRTSTHN019);2015年河南省教育技术装备和实践教育研究立项课题(GZS008);开封市创新人才项目(1509010)

摘　　要：以牛蒡、桑叶和灵芝组方,研究其水煎煮液降血糖作用。通过尾静脉注射四氧嘧啶诱导糖尿病小鼠模型。检测给药前后糖尿病小鼠血糖、肝糖原以及血清中TG、TCH、SOD和MDA含量的变化,考察复方对糖尿病小鼠血糖、脂质代谢和氧化应激的影响。结果表明:高剂量组能显著的升高SOD的水平(p<0.01),降低空腹血糖(p<0.05)、TCH(p<0.05)、TG(p<0.01)和MDA的含量(p<0.01);中剂量组能显著的升高SOD的水平(p<0.01),降低空腹血糖(p<0.05)、TCH(p<0.05)、TG(p<0.05)和MDA的含量(p<0.05);低剂量组能显著升高SOD(p<0.01)、肝糖原水平(p<0.05);降低TCH(p<0.05)和TG的含量(p<0.01)。结果表明:牛蒡、桑叶和灵芝方水提取物具有降低糖尿病小鼠空腹血糖,改善糖尿病小鼠脂质代谢紊乱和增强糖尿病小鼠抗氧化应激的作用。Burdock,mulberry leaf and ganoderma lucidum were used as the raw material, the decoction of fructus arctii,mulberry leaf, ganoderma lucidum compound was prepared by the water extracts.The change of blood sugar, hepatic glycogen, and serum TG,TCH, SOD, MDA was measured in the diabetic mice model established by the tail vein injection of alloxan.The effects of the compound extract was reflected on diabetes mice blood glucose, lipid metabolism, oxidative stress. The results showed that high dose group of water extract compound could significantly increase the content of SOD（p 〈0.01） ,and decrease the content of fasting blood（p 〈0.05） ,TCH（p 〈 0.05） ,TG（p 〈 0.001 ）and MDA （p 〈 0.05）. Medium dose group of water extract compound could significantly increase the content of SOD （ p 〈 0.01 ）, and decrease the content of fasting blood （ p 〈 0.05 ）, TCH （ p 〈 0.05 ） and MDA（p 〈0.05）.Low dose group of water extract compound could significantly increase the contents of SOD（p 〈 0.01 ） and liver glycogen （ p 〈 0.05 ）, and decrease the content of TCH （ p 〈 0.05 ） and TG （ p 〈 0.0] ）. Results indicated that the water extract compound of burdock, mulberry leaf and ganoderma lucidum had significant hypoglycemic effect,and rectified the derangement in lipide metabolism and strengthen antioxidant defense system.

关 键 词：牛蒡 桑叶 灵芝 水提法 糖尿病 

分 类 号：TS218[轻工技术与工程—粮食、油脂及植物蛋白工程]