氧化应激中ROS对FOXO3a转录因子的调控作用研究进展  

Redox regulation of FOXO3a transcription factor

作　　者：李昂[1] 邢雅琪 李晓霞[1] 章吉威 郭会彩[1] LI Ang XING Ya-qi LI Xiao-xia ZHANG Ji-wei GUO Hui-cai(Dept of Toxicology, Hebei Medical University, Shijiazhuang 050017, China)

机构地区：[1]河北医科大学卫生毒理学教研室,河北石家庄050017

出　　处：《中国药理学通报》2016年第9期1203-1207,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金资助项目(No 81473292);2016年河北省"大学生创新性实验计划"项目(No USIP2016020)

摘　　要：活性氧(reactive oxygen species,ROS)介导的氧化应激参与多种细胞信号转导过程,FOXO3a转录因子是氧化应激中多个信号通路的交汇点,ROS对FOXO3a存在着复杂的调控作用。由于FOXO3a在细胞增殖、细胞周期阻滞、ROS清除和诱导细胞凋亡中发挥复杂而重要的作用,已经成为氧化应激损伤的研究热点之一。该文对氧化应激损伤中FOXO3a的活性调节机制及其靶基因进行了综述,为FOXO3a靶向调控氧化应激和临床治疗相关疾病开辟了新的思路。ROS-mediated oxidative stress involved in a variety of cellular signal transduction,FOXO3 a transcription factor is an intersection in regulating a variety of cellular oxidative stress.Fox O3 a has been extensively studied in regulating oxidative stress because of its rather complex and pivotal regulation of cell proliferation,cell cycle arrest,ROS scavenging and apoptosis.This review will elucidate the FOXO3a＇s regulatory mechanisms and describe the target genes involved. It will also provide the clinical significance and strategies to target FOXO3 a to regulate oxidative stress.

关 键 词：氧化应激 ROS FOXO3A 调控作用 磷酸化作用 抗氧化酶 

分 类 号：R05[医药卫生] R329.2