Phosphorylation of group I metabotropic glutamate receptors in drug addiction and translational research  

作　　者：Limin Mao John Q Wang 

机构地区：[1]Department of Basic Medical Science, School of Medicine, University of Missouri-Kansas City, Kansas City, M0 64108, USA

出　　处：《Journal of Translational Neuroscience》2016年第1期17-23,共7页转化神经科学电子杂志（英文）

摘　　要：Protein phosphorylation is an important posttranslational modification of group I metabotropic glutamate receptors （ mGluR1 and mGluR5 subtypes, mGluR1/5 ） which are widely distributed throughout the mammalian brain. Several common protein kinases are involved in this type of modification, including protein kinase A, protein kinase C, and extracellular signal-regulated kinase. Through constitutive and activity-dependent phosphorylation of mGluR1/5 at specific residues, protein kinases regulate trafficking, subcellular/subsynaptic distribution, and function of modified receptors. Increasing evidence demonstrates that mGluR1/5 phosphorylation in the mesolimbic reward circuitry is sensitive to chronic psychostimulant exposure and undergoes adaptive changes in its abundance and activity. These changes contribute to long-term excitatory synaptic plasticity related to the addictive property of drugs of abuse. The rapid progress in uncovering the neurochemical basis of addiction has fostered bench-to-bed translational research by targeting mGluR1/5 for developing effective pharmacotherapies for treating addiction in humans. This review summarizes recent data from the studies analyzing mGluR1/5 phosphorylation. Phosphorylation-dependent mechanisms in stimulant-in-duced mGluR1/5 and behavioral plasticity are also discussed in association with increasing interest in mGluR1/5 in translational medicine.

关 键 词：MGLUR PKA PKC MAPK ERK STRIATUM nucleus accumbens G protein-coupled receptors 

分 类 号：R[医药卫生]