脑白质疏松与亚甲基四氢叶酸还原酶基因多态性的研究  

Leukoaraiosis and methylenetetrahydrofolate reductase gene polymorphism

作　　者：张文芳[1] 马宏[1] 吴桂英[1] 王丽霞[1] 白燕[1] 冯瑞公 张家贵[1] 任斌[1] 李丽娜[1] 

机构地区：[1]内蒙古医学院第四附属医院(内蒙古第一机械集团有限公司医院)神经内科,包头014032

出　　处：《中华老年心脑血管病杂志》2016年第12期1294-1297,共4页Chinese Journal of Geriatric Heart,Brain and Vessel Diseases

基　　金：包头市科技计划项目(2015s2004-4-5)

摘　　要：目的探讨影响脑白质疏松（leukoaraiosis, LA）形成的相关因素，并分析亚甲基四氢叶酸还原酶（MTHFR）基田多态性对LA发病的影响。方法收集20t5年1月-2016年3月在我院接受治疗的134例LA患者作为LA组和73例健康体检的老年人作为对照组，收集受试者的一般临床资料并进行相关生化检测。对照纽70倒、LA组131例患者进行MTHFR的2个基因C667T及At298CPCR扩增和基因多态性分析。结果logistic回归分析显示，年龄（95％CI：1．877～5．134，P=0．000）、高血压（95％CI：1．223～4．631，P=0．011）、同型半胱氨酸（95％CI：1．647-6，090，P=0．001）为LA的独立危险因素。2组患者C677T不同基因分型和碱基比例比较，差异无统计学意义（P〉0．05）。A1298C不同基因分型和碱基比例比较，差异有统计学意义（P〈0．05）。结论LA与MTHFRC667T基因多态性无相关，MTHFRA1298C基因突变可能与LA的发病相关。Objective To study the factors of leukoaraiosis （LA） and analyze the effect of methyle- netetrahydrofolate reductase （MTHFR） gene poIymorphism on LA. Methods One hundred and thirty-four LA patients admitted to our hospital from January 2015 to March 2016 served as a LA group and 73 healthy elderly people undergoing physical examination served as a control group in this study. Their general clinical data and laboratory parameters were recorded. MTHFR C667T and A1298C were amplified and their polymorphisms were analyzed. Results Logistic regression analysis showed that age, hypertension and homochysteine were the independent risk factors for LA （95GCI：1. 877-5. 134,P=0. 000;95GCI：1. 223-4. 631,P=0. 011;95%CI.1. 647-6. 090, P=0. 001）. No significant difference was found in genotypes and base pairs of C677T between the two groups （P〉0.05） ,but a significant difference was found in those of A1298C between the two groups （P〈0.05）. Conclusion LA is not related with the MTHFR C667T polymorphysim but is related with the MTHFR A1298C mutation.

关 键 词：脑白质疏松症 亚甲基四氢叶酸还原酶 高血压 高半胱氨酸 突变 

分 类 号：R743[医药卫生—神经病学与精神病学]