硫酸头孢噻利E型异构体的合成工艺研究  

Synthesis of trans-isomer of cefoselis sulfate

作　　者：刘志友[1] 叶俊杰[1] 孟红[1] 赵平[1] 

机构地区：[1]天津市医药集团技术发展有限公司,天津300193

出　　处：《现代药物与临床》2016年第11期1689-1691,共3页Drugs & Clinic

基　　金：天津市科技支撑计划重点项目(05YFGZGX03100)

摘　　要：目的对硫酸头孢噻利E型异构体的合成工艺进行研究。方法以氨噻肟酸为起始原料,定向合成硫酸头孢噻利E型异构体。结果合成了目标化合物硫酸头孢噻利E型异构体,并利用1H-NMR、MS确证了结构。精制收率为16.0%,HPLC面积归一化法测得质量分数为94%。结论制备了硫酸头孢噻利E型异构体,为硫酸头孢噻利中杂质研究提供参考。Objective To study the synthetic technology of E-isomer of cefoselis sulfate. Methods Aminothiaoximo acid was used as the starting material to synthesize E-isomer of cefoselis sulfate. Results The target compound was synthesized and characterized by 1H-NMR and MS. The purified yield of this synthetic route was 16.0%, and the purity of E-isomer of cefoselis sulfate was 94%. Conclusion E-isomer of cefoselis sulfate is obtained which provides reference for impurity study of cefoselis sulfate.

关 键 词：硫酸头孢噻利 E型异构体 氨噻肟酸 合成工艺 

分 类 号：R914[医药卫生—药物化学]