α-糜蛋白酶催化合成喹啉衍生物  

Synthesis of Quinoline Derivatives Catalyzed by α-Chymotrypsin

作　　者：梁萌[1] 谢宗波[2,1] 艾锋[1] 乐长高[2,1] 

机构地区：[1]东华理工大学应用化学系,南昌330013 [2]东华理工大学江西省质谱科学与仪器2011协同创新中心,南昌330013

出　　处：《有机化学》2016年第11期2704-2708,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金(Nos.21262002;21462001;21465002);长江学者和创新团队发展计划(No.IRT13054);江西省自然科学基金(No.20142BAB203008)资助项目~~

摘　　要：首次以α-糜蛋白酶为生物催化剂,通过2-氨基芳基酮和α-亚甲基酮之间的Friedl?nder缩合反应,合成了11种喹啉衍生物,取得了中等至优异的产率.该方法操作简便,条件温和,不仅拓展了蛋白酶非专一性及生物催化的应用范围,对推动绿色化学的发展也具有积极意义.The α-chymotrypsin-catalyzed Friedl^inder condensation reaction between 2-aminoaryl ketone and a-methylene ketone was firstly reported, and a series of quinoline derivatives were obtained in moderate to excellent yields. This method is easy to operate and the reaction condition is mild, which not only expands the application of the promiscuity of protease, but also has positive significance for promoting the development of the green chemistry.

关 键 词：日一糜蛋白酶 Friedlander缩合反应 喹啉衍生物 生物催化 

分 类 号：O626.323[理学—有机化学]