基于崩解时限的牡蛎糖原片剂配方组合优化研究  

Optimization research of the formulation of oyster glycogen tablets basing on disintegration time

作　　者：刘淑集[1] 许雅洁[2] 刘智禹[1] 冷波[2] 苏永昌[1] 王茵 许旻[1] 

机构地区：[1]福建省水产研究所福建省海洋生物增养殖与高值化利用重点实验室福建省海洋生物资源开发利用协同创新中心,福建厦门361013 [2]闽南师范大学菌物工程技术研究中心,福建漳州363000

出　　处：《渔业研究》2016年第6期453-459,共7页Journal of Fisheries Research

基　　金：福建省海洋高新产业发展专项(闽海洋高新〔2014〕20号);厦门市海洋经济创新发现区域示范项目(12CZP001SF02);福建省科技重大专项(2014NZ0001-1);闽台重要海洋生物资源高值化开发技术公共服务平台(2014FJPT01);福建重要海洋经济生物种质库与资源高效开发技术公共服务平台(14PZY017NF17)

摘　　要：为了确定牡蛎糖原片剂的制备工艺,以崩解时限为重要指标,利用单因素结合正交试验法筛选优化牡蛎糖原片剂配方组合。研究结果表明,以牡蛎糖原冻干粉添加量15%、微晶纤维素15%、麦芽糊精5%、羧甲基淀粉钠5%、硬脂酸镁0.02%、玉米淀粉59.98%为片剂处方,优选出的处方工艺简单可行,制备的片剂质量符合中国药典(2015版)的有关规定,稳定性好。To develop the preparation technique of oyster glycogen tablets, the preparation technique of oyster glycogen tablets was optimized by single factor and orthogonal experiment, with the disintegration time as important quality indicators. Results showed that, the optimum ratio of oyster glycogen freeze - dried powder, MCC, mahodextrin, CMS -Na, magnesium stearate and corn starch were 15%, 15%, 5%, 5%, 0. 02% and 59. 98%, respectively. The optimal process was simple and feasible to conduct, and the quality of the optimized oyster glycogen tablets had a good stability, which met the criterion of Chinese Pharmacopoeia （2015）.

关 键 词：牡蛎糖原 片剂 工艺 

分 类 号：S986.1[农业科学—捕捞与储运]