XYLB基因rs17118多态性与中国汉族人群缺血性卒中关联研究  

Correlation between rs17118 polymotphism of XYLB gene and ischemic stroke in a Chinese Hart population

作　　者：李山山[1] 张艳炜[2] 黄素丽[2] 谢昌辉[2] 程锦泉[1,2] 

机构地区：[1]郑州大学公共卫生学院,450001 [2]深圳市疾病预防控制中心,518055

出　　处：《国际脑血管病杂志》2016年第10期898-901,共4页International Journal of Cerebrovascular Diseases

基　　金：国家自然科学基金青年科学项目（81402755）

摘　　要：目的验证木酮糖激酶（xylulokinasehomolog,XYLB）基因rsl7118多态性与中国汉族人群缺血性卒中发病风险的关联性。方法采用病例对照研究设计，病例组为首发缺血性卒中患者，对照组为医院体检者，采用Taqman探针荧光定量聚合酶链反应技术检测rsl7118C／A多态性的基因型分布。结果共纳入475例缺血性卒中患者和483例对照者。病例组高血压（67．9％对22．2％；z。=292．982，P〈0．001）、糖尿病（24．2％对7．3％；X2=25．864，P〈0．001）的患者比例以及三酰甘油[（1．649±1．126）mmol／L对（1．157±1．480）mmol／L）；t=3．592，P〈0．001]和低密度脂蛋白胆固醇[（3．499±1．163）mmol／L对（3．105±0．627）mmol／L；t=-6．227，P〈0．001]水平显著高于对照组，但总胆固醇水平显著低于对照组[（5．144±1．296）mmol／L对（5．491±1．335）mmol／L；t=4．650，P〈0．001]。病例组AA基因型（11．4％对7．5％；X2=6．136，P=0．016）以及A等位基因（32．3％对26．4％；X2=8．093，P=0．005）频率均显著高于对照组。多变量logistic回归分析显示，在校正传统危险因素后，AA基因型携带者的缺血性卒中患病风险是CC基因型携带者的1．971倍（优势比1．971，95％可信区间1．040～3．736；P=0．038）。结论XYLB基因rsl87118C／A多态性与中国汉族人群缺血性卒中的发病风险有关。Objective To verify the correlation between rs17118 polymorphism of xyluloknase homolog （XYLB） we and risk of ischemic stroke in a Chinese Han population. Methods A case-control study design was used. The case group was the patients with first-ever ischemic stroke and the control group was the healthy subjects from hospital physical examination. Taqman probe fluorescence quantitative polymerase chain reaction technique was used to detect the genotype distribution of rs17118 C/A polymorphisms. Results A total of 475 patients with ischemic stroke and 483 controls were enrolled in the study. The proportion of hypertension （67.9% vs. 22.2% ; X2 = 292. 982, P 〈 0. 001 ） and diabetes （24.2% vs. 7.3%; X2= 25.864, P〈 0.001）, as well as the levels of triacylglycerol （1.649± 1. 126 mmol/L vs. 1. 157 ± 1. 480 mmol/L; t = 3. 592, P 〈 0. 001）, and low-density lipoprotein cholesterol （3. 499 ± 1. 163 mmol/L vs. 3. 105 ± 0. 627 mmol/L; t = -6. 227, P〈 0. 001 ） in the case group were significantly higher than those in the control group, but the total cholesterol level was significantly lower than that in the control group （5. 144 ± 1. 296 mmol/L vs. 5.491 ± 1. 335 mmol/L; t =4. 650, P〈0. 001）.The AA genotype （11.4% vs. 7.5% ;x2 =6. 136, P =0. 016） and A allele （32. 3% vs. 26.4% ;X2 =8. 093, P =0. 005） frequencies in the case group were significantly higher than those in the control group. Multivariate logistic regression analysis showed that after adjusting for traditional risk factors, the risk of ischemic stroke in AA ~notype carriers was 1.97 times of the CC genotype carriers （odds ratio 1. 971, 95% confidence interval 1. 040-3. 736, P =0. 038）. Conclusions The rsl7118C/A polymorphism of XYLB ~ne may be associated with the risk of ischemic stroke in the Chinese Han population.

关 键 词：卒中 脑缺血 磷酸转移酶类(醇族体) 多态现象 遗传学 疾病遗传易感性 汉族 危险因素 木酮糖激酶 

分 类 号：R743.3[医药卫生—神经病学与精神病学]