先天性15颗恒牙缺失伴乳牙列1例报道并文献复习  

Congenital Missing of 15 Permanent Teeth with Deciduous Dentition:A Case Report and Literature Review

作　　者：朱远平[1] ZHU Yuanping(The Second People ＇ s Hospital of Yichang City The Second People ＇ s Hospital of Three Gorges University, Yichang 443000, Hubei , Chin)

机构地区：[1]湖北省宜昌市第二人民医院/三峡大学第二人民医院,湖北宜昌443000

出　　处：《武汉大学学报（医学版）》2017年第1期155-158,共4页Medical Journal of Wuhan University

摘　　要：目的:通过分析1例先天性恒牙缺失15颗伴乳牙列患者的临床特点,并结合文献来探讨该病的发生机制。方法:对我院确诊的1例先天性恒牙缺失15颗伴乳牙列患者的临床资料进行分析及文献复习。结果:该患者自幼身体健康,无传染病史和内分泌病史,无创伤及严重感染史,主要临床表现为多数恒牙的缺失,牙列稀疏,过大牙、过小牙及乳牙列同时并存。结论:先天性多颗牙缺失者,并非一定是外胚叶发育不全综合征的表现,非综合征性多颗牙先天缺失也有发生,过大牙过小牙或为牙先天缺失的一种特殊表现,发病机制可能与遗传因子的突变有关。Objective：To report one case of oligodontia of 15 permanent teeth with primary dentition,and to study the mechanism of the disease by literature review.Methods：The clinical data of a patient diagnosed with oligodontia of 15 permanent with primary dentition were analyzed and the related literature were reviewed.Results：The patient has been healthy and had no history of infectious diseases,endocrine,trauma and severe infection since childhood,and the clinical manifestation mainly shows the oligodontia of the majority of permanent teeth,sparse toothscattered dentition,and macrodontia,microdontia and primary dentition coexist.Conclusion：As for patients with oligodontia of several teeth,it may not be expression of Hypohidrotic Ectodermal Dysplasia.However,non-syndromic congenital absence of several teeth may occur.Macrodontia and microdontia might be a special form of oligodontia.And the pathogenesis may be related to the mutations of genetic factors.

关 键 词：多数牙先天缺失 基因 突变 

分 类 号：R788[医药卫生—口腔医学]