中性粒细胞在肿瘤中作用的研究进展  

The advances in the role of neutrophils in cancer

作　　者：张文[1] 张鹏[1] 徐雪莹[1] 许文荣[1] 张徐[1] 

机构地区：[1]江苏大学医学院江苏省检验医学重点实验室,江苏镇江212013

出　　处：《肿瘤》2017年第1期96-100,共5页Tumor

基　　金：国家自然科学基金面上项目(编号:81672416);江苏省科技项目(编号:BK20141303)~~

摘　　要：近年来研究发现,中性粒细胞具有表型和功能可塑性。一方面,中性粒细胞可通过细胞毒和免疫活化作用发挥抗肿瘤效应;另一方面,在肿瘤及其微环境作用下中性粒细胞可发生表型和功能转变,推动肿瘤发生、生长和转移,促进肿瘤血管生成,以及介导肿瘤免疫抑制。临床研究表明,肿瘤患者外周血和肿瘤组织中性粒细胞数量增加,且与肿瘤恶性进展及预后不良密切相关。本文就中性粒细胞在肿瘤中的作用、机制以及临床意义进行综述。In recent years, increasing studies have shown that neutrophils have phenotypic and functional plasticity. On one hand, neutrophils could exert anti-tumor activities through cytotoxicity and activation of innate and adaptive immune responses. On the other hand, tumor and its microenvironment could induce the conversion of neutrophil phenotype and function, leading to the promotion of tumorigenesis, tumor growth and metastasis, the stimulation of tumorangiogenesis, and the induction of immunosuppression. The clinical studies have shown that increased number of neutrophils in the blood and tumor tissues is associated with disease progression and poor prognosis of cancer patients. This paper summarizes the advances in the role, mechanism and clinical value of neutrophils in cancer.

关 键 词：肿瘤 诊断 治疗 中性粒细胞 

分 类 号：R730.231[医药卫生—肿瘤]