精准医疗与胰腺癌  

Role of precision medicine in pancreatic cancer

作　　者：朱世凯[1] Shi-Kai Zhu(Organ Transplant Center, Hospital of University of Electronic Science and Technology of Chin Sichuan Provincial People＇s Hospital, Chengdu 610072, Siehuan Province, China)

机构地区：[1]电子科技大学附属医院.四川省人民医院器官移植中心,四川省成都市610072

出　　处：《世界华人消化杂志》2016年第36期4752-4758,共7页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目;No.81402029~~

摘　　要：胰腺癌是现代肿瘤学中最具挑战性的难题之一.由于胰腺癌早期诊断极其困难,且较早可发生远处转移,手术切除率不足20%,预后极差.尽管对胰腺癌的诊疗经历多年的艰苦探索,但其生存率并没有明显的提高.因此,早期诊断和治疗是提高胰腺癌患者生存率的关键问题所在.随着基因组学大数据时代的来临和生物技术的迅速发展,最近提出的精准医疗的新理念已经迅速成为全球医学界热议和高度关注的焦点.本文阐述近些年来精准医疗理念在胰腺癌临床运用中的现状以及所面临的机遇和挑战,为进一步提高胰腺癌患者的生存率提供新思路.Pancreatic cancer is one of the most challenging problems in modern oncology.Due to difficultly in early diagnosis and early distant metastasis of pancreatic cancer,surgical resection rate is less than 20%and patients＇ prognosis is very poor.Despite long-term efforts taken to develop treatments for pancreatic cancer,the survival rate did not significantly improve.Therefore,early diagnosis and treatment are the key to improve the survival rate of patients with pancreatic cancer.The advent of big-data genomic era and the rapid development of biotechnology have led to the recent proposal of a new concept of precise medicine,which has quickly become the focus of world medical conferences.Here,we describe the new progress and challenges of precision medicine in pancreatic cancer,with an aim to provide new ideas for improving the survival rate of patients with pancreatic cancer.

关 键 词：胰腺癌 精准医疗 基因诊断 靶向治疗 

分 类 号：R735.9[医药卫生—肿瘤]