四种新疆发酵驼乳源益生菌对小鼠的免疫调节作用  

Immunoregulatory effects of four probiotics derived from Xinjiang fermented camel milk in mice

作　　者：肖雪筠 张奕[1] 新华.那比[1] 

机构地区：[1]新疆医科大学药理教研室,新疆乌鲁木齐830011

出　　处：《食品工业科技》2017年第4期337-341,共5页Science and Technology of Food Industry

基　　金：国家自然科学基金(81160344)

摘　　要：目的:探究新疆传统发酵驼乳及乳酪乳清中分离出的四种益生菌对环磷酰胺所致免疫低下小鼠免疫功能的调节和保护作用。方法:利用环磷酰胺(80 mg·kg^(-1),ip)制造免疫低下小鼠模型,随机分为11个组,分别灌胃高、低剂量的马乳酒样乳杆菌,东方伊萨酵母菌,高加索酸奶乳杆菌以及戊糖乳杆菌。结果:与模型组相比,四种益生菌组小鼠体重、脾脏、胸腺指数以及脾淋巴细胞增殖活力均有增加(p<0.01);血清谷草转氨酶(AST)、谷丙转氨酶(ALT)以及尿素氮(UREA)水平出现不同程度降低(p<0.05);Th1型细胞因子增多(p<0.01)。结论:四种益生菌能够部分缓解环磷酰胺对小鼠免疫抑制作用,调节Th1/Th2平衡,起到免疫调节和保护作用。Objective： To expolre the immunoregulatory and protective effects of four kinds of probiotics that were isolated from Xinjiang traditional fermented camel milk and cheese whey. Method： Use CTX（ 80 mg / kg,ip） to establish the immunosuppressive mouse model,then they were randomly assigned into 11 groups,we gave high and low dose of Lactobacillus kefiranofaciens,yeast Issa Oriental,Lactobacillus kefir,and Lactobacillus pentosus. Result： Compared with the model group,the body weight,spleen,thymus index,and lymphocyte proliferation ablity were increased（ P〈0.01）,AST,ALT,UREA were decreased（ P〈0.05）,the content of Th1 cytokines were increased（ P〈0.01）.Conclusion： These four probiotics could alleviated the immunosuppressive effects,regulated the Th1 / Th2 balance,and played the role of immune regulation and protection.

关 键 词：益生菌 免疫 细胞因子 

分 类 号：TS201.4[轻工技术与工程—食品科学]