Core-shell Au@MnO2 nanoparticles for enhanced radiotherapy via improving the tumor oxygenation  

作　　者：Xuan Yi Lei Chen Xiaoyan Zhong Roulin Gao Yitao Qian Fan Wu Guosheng Song Zhifang Chai Zhuang Liu Kai Yang 

机构地区：[1]School of Radiation Medicine and Protection & School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China [2]Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center ofSuzhou Nano Science and Technology, Soochow University, Suzhou 215123, China

出　　处：《Nano Research》2016年第11期3267-3278,共12页纳米研究（英文版）

基　　金：This work was partially supported by the National Basic Research Program of China （973 Program, Nos. 2014CB931900 and 2012CB932600）, National Natural Science Foundation of China （Nos. 81471716 and 31400861）, the National Natural Science Foundation of Jiangsu Province （No. BK20140320）, and a Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions （PAPD）.

摘　　要：Local hypoxia in solid tumors often results in resistance to radiotherapy （RT）, in which oxygen is an essential element for enhancing DNA damage caused by ionizing radiation. Herein, we developed gold@manganese dioxide （Au@MnO2） core-shell nanoparticles with a polyethylene glycol （PEG） coating as a novel radiosensitizing agent to improve RT efficacy during cancer treatment. In this Au@MnO2 nanostructure, while the gold core is a well-known RT sensitizer that interacts with X-rays to produce charged particles for improved cancer killing under RT, the MnO2 shell may trigger the decomposition of endogenous H2O2 in the tumor microenvironment to generate oxygen and overcome hypoxiaassociated RT resistance. As demonstrated by both in vitro and in vivo experiments, Au@MnO2-PEG nanoparticles acted as effective radiosensitizers to remarkably enhance cancer treatment efficacy during RT. Moreover, no obvious side effects of Au@MnO2-PEG were observed in mice. Therefore, our work presents a new type of radiosensitizer with potential for enhanced RT treatment of hypoxic tumors.Local hypoxia in solid tumors often results in resistance to radiotherapy （RT）, in which oxygen is an essential element for enhancing DNA damage caused by ionizing radiation. Herein, we developed gold@manganese dioxide （Au@MnO2） core-shell nanoparticles with a polyethylene glycol （PEG） coating as a novel radiosensitizing agent to improve RT efficacy during cancer treatment. In this Au@MnO2 nanostructure, while the gold core is a well-known RT sensitizer that interacts with X-rays to produce charged particles for improved cancer killing under RT, the MnO2 shell may trigger the decomposition of endogenous H2O2 in the tumor microenvironment to generate oxygen and overcome hypoxiaassociated RT resistance. As demonstrated by both in vitro and in vivo experiments, Au@MnO2-PEG nanoparticles acted as effective radiosensitizers to remarkably enhance cancer treatment efficacy during RT. Moreover, no obvious side effects of Au@MnO2-PEG were observed in mice. Therefore, our work presents a new type of radiosensitizer with potential for enhanced RT treatment of hypoxic tumors.

关 键 词：enhanced radiotherapy RADIOSENSITIZER HYPOXIA high-Z element core-shell structure 

分 类 号：Q2[生物学—细胞生物学] TH774[机械工程—仪器科学与技术]