液相色谱柱进展及其在药品标准中的应用  

Advancement and application of liquid chromatographic column packings in the standardization of drugs

作　　者：洪小栩[1] 石莹[2] 宋雪洁[2] 雷启福[3] 黄悯嘉[3] 丛科[3] 王玉 钱忠直[1] 

机构地区：[1]国家药典委员会,北京100061 [2]扬子江药业集团,泰州225321 [3]安捷伦科技(中国)有限公司,上海200080 [4]江苏省食品药品监督检验研究院,南京210008

出　　处：《药物分析杂志》2017年第2期191-201,共11页Chinese Journal of Pharmaceutical Analysis

摘　　要：色谱柱技术发展促进了高效液相色谱法在药物分析中更为广泛的应用。本文基于液相色谱柱及其填料的分类和核心技术进展,分析了液相色谱柱在药品标准中的应用情况,对在药品标准中使用和描述色谱柱提出一些建议,并论述了多种色谱分离模式的应用前景。The development of chromatographic column technologies has promoted the widespread applications of high performance chromatography in pharmaceutical analysis.Based on the advancement of various types of liquid chromatographic column packings and key technologies,the applications of liquid chromatographic columns in the standardization of drugs were discussed,the recommendations on how to properly use and describe the columns in drug standardization were provided,and the application perspectives of various chromatographic separation modes were also reviewed.

关 键 词：高效液相色谱 色谱柱 填料分类 核心技术 药品标准 中国药典 美国药典 英国药典 

分 类 号：R917[医药卫生—药物分析学]