乳杆菌属治疗肠易激综合征的机制  

Mechanism of Lactobacillus in the treatment of irritable bowel syndrome

作　　者：陆佳[1] 方秀才[1] 

机构地区：[1]中国医学科学院北京协和医学院北京协和医院消化内科,北京100730

出　　处：《胃肠病学和肝病学杂志》2017年第2期218-221,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肠易激综合征(IBS)是一种常见的功能性胃肠病,其病因及发病机制尚未完全明确。临床研究表明益生菌能有效治疗IBS,其中应用较多的是乳杆菌属。本文将从改善内脏高敏感性、肠道动力、调节肠道微生态平衡、改善肠道通透性、抑制炎症反应、改善精神心理异常及抑菌作用等方面对乳杆菌属治疗IBS的疗效机制作一概述。Irritable bowel syndrome（IBS） is one of the most common functional gastrointestinal disorders,of which the causes and pathogeneses are not yet clear. The clinical studies have demonstrated that probiotics may be an effective treatment of IBS,especially in lactobacillus. This review was focused on the effects of lactobacillus and the related therapeutical mechanism such as improvement of visceral hypersensitivity and intestinal motility,restoration of gut microbiota and intestinal barrier function,inhibition of mucosal inflammation,improvement of the mental abnormalities,activities of antimicrobia and so on.

关 键 词：肠易激综合征 益生菌 乳杆菌属 机制 

分 类 号：R574.4[医药卫生—消化系统]