大蒜提取物对铜绿假单胞菌生物膜形成的影响  

Effect of garlic extract on development of biofilm in Pseudomonas aeruginosa

作　　者：丁荣荣[1] 陈贵堂[1] 杨志萍[1] 王海翔[1] 綦国红[1] 

机构地区：[1]中国药科大学工学院,江苏南京211198

出　　处：《食品与发酵工业》2017年第2期85-89,共5页Food and Fermentation Industries

基　　金：基金项目:细菌群体感应对鱼虾腐败过程的调控作用及其分子机制(30700627)

摘　　要：研究了大蒜提取物对铜绿假单胞菌PAO1生物膜形成的影响。通过对铜绿假单胞菌PAO1生物膜以及与生物膜形成相关因素的测定,结果表明大蒜提取物在不影响PAO1生长的浓度条件下,能抑制其生物膜的形成、胞外多糖的产生以及浮游现象;与阿奇霉素具有协同作用。因此,大蒜提取物通过干扰铜绿假单胞菌PAO1群体感应系统来抑制其生物膜的形成,降低与生物膜形成相关特性的表达。The effect of garlic extract on the development of biofilm in Pseudomonas aeruginosa PAO1 was studied. The biofilm production and factors correlated with the biofilm formation in PAO1 were evaluated. The results showed that the garlic extract not only inhibited the development of biofilm, extracellular polysaccharide production, and motility characteristic, but also had synergistic effect with Azithromycin when the concentration of garlic extractdidn＇ t affect growth of PAO1. The results suggested that garlic extract could inhibit the development of biofilm and reduce the expression of factors correlated with the biofilm formation in P. aeruginosa PAO1 by interfering with their QS systems.

关 键 词：铜绿假单胞菌 生物膜 大蒜提取物 群体感应抑制 

分 类 号：TS201.3[轻工技术与工程—食品科学]