脑心通胶囊联合阿司匹林对短暂性脑缺血患者的疗效及血液流变学指标的影响  

The effect of Naoxintong Capsules combined with aspirin on the treatment of transient ischemic attack

作　　者：金朗 王雪[2] 王炳强 林高平[4] 

机构地区：[1]沧州市人民医院,沧州061001 [2]沧州医学高等专科学校,沧州061001 [3]沧州市妇幼保健院,沧州061001 [4]浙江省人民医院,杭州310014

出　　处：《中药药理与临床》2016年第6期206-209,共4页Pharmacology and Clinics of Chinese Materia Medica

摘　　要：目的:观察脑心通联合阿司匹林对短暂性脑缺血患者疗效和对血液流变学指标的影响。方法:纳入2013年6月至2014年5月我院收治的短暂性脑缺血患者87例,按随机数字表法分为观察组43例和对照组44例。对照组给予阿司匹林进行治疗,观察组患者在对照组用药基础上加用脑心通联合治疗。观察两组患者治疗六个月后的临床疗效,治疗2个月后对两组患者血液流变学指标进行对比分析。结果:治疗后观察组总有效率为93.02%,明显高于对照组72.73%。治疗后观察组全血黏度高切和全血黏度低切水平分别为(4.52±0.25、5.46±0.44)m Pa/s,均明显低于对照组(5.20±0.41、7.01±0.52)m Pa/s。3治疗后观察组患者血浆黏度和纤维蛋白原水平分别为(1.50±0.05m Pa/s、2.62±0.32g/L),均明显低于对照组(1.69±0.08m Pa/s、3.31±0.43g/L)。4治疗后观察组血小板聚集率和红细胞比容分别为(49.72±3.01、43.04±1.14)%,均明显低于对照组(60.13±3.18、45.16±1.72)%。结论:脑心通联合阿司匹林的治疗方案可提高短暂性脑缺血患者的治疗疗效,改善患者血液流变学指标,是一种有效的治疗方法。Objective： To observe the effect of Naoxintong Capsules combined with aspirin on the treatment of Transient ischemic attack. Methods：87 patients with transient cerebral ischemia from June 2013 to May 2014 were randomly divided into observation group with 43 cases and the control group with 44 eases . The control group received aspirin therapy, observation group received Naoxintong capsules combinng with aspirin therapy. To observe the clinical efficacy of two groups after six months treatment and hemorheology in both groups after 2 months of treat- ment. Results： ①After six months treatment, total effective rate of the observation group was 93.02%, higher than the control group with 72.73% , and the difference was significant （ P 〈 0.05）. ②After two months treatment, the whole blood viscosity high shear and whole blood viscosity low shear levels of the observation group were （ 4.52 ± 0.25,5.46 ± 0.44） mPa/s, lower than the control group with （ 5.20 ± 0.41 7.01 ± 0.52） mPa/s, and the differences were statistically significant （ P 〈 0.05 ）. ③After two months treatment, the plasma viscosity and fibrinogen levels of the observation group were （ 1.50 ±0.05mPa/s, 2.62 ±0.32g/L）, Were lower than the control group with （ 1.69 ± 0. 08mPa/s, 3.31 ± 0.43g/L ）, and the differences were statistically significant （P 〈 0.05 ）. ④After two months treatment, the platelet aggre-gation rate and hematocrit of the observation group were （49.72 ± 3.01,43.04 ± 1.14 ） %, lower than the control group with （60.13 ± 3.18, 45.16 ± 1.72）%. Conclusion： Naoxintong capsules combing with aspirin can improve the efficaey of patients with transient ischemic attack and improve patient blood rheology.

关 键 词：脑心通 阿司匹林 暂性脑缺血 血液流变学 

分 类 号：R743.31[医药卫生—神经病学与精神病学]