原发灶不明转移癌的临床诊断  

Clinical diagnostic approaches for carcinoma of unknown primary

作　　者：陈金影 蔡虎 徐清华 

机构地区：[1]杭州可帮基因科技有限公司,浙江杭州311188

出　　处：《分子诊断与治疗杂志》2017年第1期67-72,共6页Journal of Molecular Diagnostics and Therapy

摘　　要：原发灶不明转移癌是一类经病理学诊断确诊为转移性,但是无法明确原发位点的恶性肿瘤。在全球范围内,原发灶不明转移癌是最常见的十大恶性肿瘤之一,死亡率位列第4。原发灶不明转移癌的治疗以经验性化疗为主,患者预后普遍较差。明确肿瘤的原发部位,有助于临床医生制定针对性的治疗方案,缓解患者焦虑情绪,从而提高生存率和改善生存质量。目前临床用于原发灶不明转移癌的方法主要有临床评估、影像学检查和组织病理学检查。近年来,随着分子生物学和生物信息学技术的飞速发展,基因分子检测显示出巨大的潜力,并已逐渐应用于原发灶不明转移癌的临床诊断。本文就原发灶不明转移癌的临床诊断方法相关进展作一综述。Carcinoma of unknown primary（CUP） is a heterogeneous group of patients whose primary sites cannot be found when the cancer has metastasized. It is one of the ten most common malignancies and the fourth most common cause of cancer-related death worldwide. The prognosis of patients with CUP is usually poor for those receiving empiric treatments. Identification of the primary site can ease the patient＇s anxiety and improve long- term survival with the help of more specific therapies. The current diagnostic approaches constitute clinical evaluation, medical imaging and histopathological examination. With the rapid evolution of the molecular biology and bioinformatics technology, genomic testing has shown great potential and has been gradually used for CUP diagnosis in clinic. In this article, a general description of the diagnostic approaches for CUP will be presented.

关 键 词：原发灶不明转移癌 分子诊断 基因检测 

分 类 号：R730.4[医药卫生—肿瘤]