香菇多糖对老年乳腺癌化疗病人T细胞亚群及血清IL-2、IL-6的影响  

Effect of lentinan on T cell subsets,IL-2 and IL-6 in elderly patients with breast cancer receiving chemotherapy

作　　者：华红霞[1] 任国琴[2] 孙优苗[1] 孙清[1] 

机构地区：[1]无锡市第二人民医院肿瘤科,江苏省无锡市214002 [2]无锡市第二人民医院护理部,江苏省无锡市214002

出　　处：《实用老年医学》2017年第2期157-160,共4页Practical Geriatrics

摘　　要：目的探讨香菇多糖对老年乳腺癌化疗病人T细胞亚群及血清白细胞介素-2(IL-2)、白细胞介素-6(IL-6)的影响。方法将80例于我院进行治疗的老年乳腺癌病人随机分为对照组和观察组,每组各40例。对照组病人进行化疗,观察组在对照组的基础上静脉滴注香菇多糖注射液,比较2组治疗前、后T细胞亚群(CD4^+、CD8^+、CD4^+/CD8^+)及血清IL-2、IL-6水平的变化。结果对照组治疗后CD4^+及CD4^+/CD8^+均较治疗前显著降低,差异有统计学意义(P<0.05),观察组治疗前后CD4^+、CD8^+及CD4^+/CD8^+比较差异均无统计学意义(P>0.05),且治疗后观察组CD4^+及CD4^+/CD8^+均显著高于对照组,差异有统计学意义(P<0.05);与治疗前比较,治疗后,观察组IL-2水平显著升高,对照组显著降低(P<0.05),观察组IL-6水平显著降低,对照组显著升高(P<0.05);治疗后2组间IL-2、IL-6水平比较,差异有统计学意义(P<0.05)。观察组不良反应发生率为50.00%,显著低于对照组的80.00%,差异有统计学意义(P<0.05)。结论香菇多糖辅助乳腺癌病人化疗,能够显著提高老年化疗病人CD4^+细胞活性,改善体内IL-2、IL-6水平,调节人体免疫功能,减轻免疫抑制。Objective To investigate the effect of lentinan on T cell subsets,IL-2 and IL-6 in elderly patients with breast cancer receiving chemotherapy. Methods A total of 80 elderly patients with breast cancer were randomly divided into control group（ n = 40） and treatment group（ n = 40）. The two groups recieved treatment with chemotherapy,and the observation group was additionally given lentinan. The levels of T cell subsets,IL-2 and IL-6 of two groups were compared. Results After treatment,the levels of CD4~＋and CD4~＋/ CD8~＋decreased significantly in control group（ P〈0. 05）,while showing no significant difference in observation group（ P〉0. 05）. The levels of CD4~＋and CD4~＋/ CD8~＋in observation group were significantly higher than those in control group（ P〈0. 05）. Compared with before treatment,the level of IL-2 increased significantly in observation group after treatment（ P〈0. 05） and decreased significantly in control group（ P〈0. 05）,and the level of IL-6 decreased significantly in observation group（ P〈0. 05） and increased significantly in control group（ P〈0. 05）. There was significant difference in levels of IL-2 and IL-6 between two groups（ P〉0. 05）. The incidence of adverse reaction in observation group（ 50. 00%） was significantly lower than that in control group（ 80. 00%）.Conclusions Lentinan can enhance CD4~＋activity,improving the levels of IL-2 and IL-6,regulating immune function in elderly patients with breast cancer receiving chemotherapy.

关 键 词：乳腺癌 香菇多糖 T细胞亚群 IL-2 IL-6 

分 类 号：R737.9[医药卫生—肿瘤]