消化道出血内镜治疗后降钙素原和C反应蛋白的测定及临床意义  

Determination and clinical significance of procalcitonin and C reactive protein after endoscopic treatment of gastrointestinal hemorrhage

作　　者：杜爱平[1] 翟亚娟[1] 张利伟[1] 张巍[1] 郑欣[1] 杨路[1] 禹晶[1] 王文斌[1] 

机构地区：[1]齐齐哈尔医学院附属第二医院消化内科,黑龙江齐齐哈尔161000

出　　处：《中国现代医生》2017年第2期16-18,共3页China Modern Doctor

基　　金：黑龙江省齐齐哈尔市科学技术计划项目(SFZD-2015052)

摘　　要：目的探讨消化道出血内镜治疗后降钙素原(PCT)和C反应蛋白(CRP)的测定对预防感染及应用抗生素的意义。方法选取2015年9月~2016年8月我院消化内科收治的消化道出血患者128例,将患者随机分为两组,每组64例。研究组患者接受内镜下治疗并在治疗后使用抗生素预防感染,对照组仅接受内镜治疗。观察两组患者在内镜治疗前1天、治疗后第1天、第7天的PCT与CRP水平,并记录患者的不良反应发生情况和治疗效果。结果两组患者治疗前PCT与CRP水平接近(P>0.05),治疗后研究组的PCT和CRP水平分别为(0.97±0.23)ng/m L、(7.24±2.48)ng/m L,均明显低于对照组(P<0.05)。研究组不良反应发生率少于对照组(P<0.05);研究组在治疗效果方面显著优于对照组(P<0.05)。结论对消化道出血患者采用内镜治疗后使用抗生素效果显著,有助于患者的康复。Objective To investigate the significance of procalcitonin and C reactive protein after gastrointestinal en- doscopy in the prevention of infection and the use of antibiotics. Methods A total of 128 patients with digestive tract hemorrhage admitted in our hospital from September 2015 to August 2016 were randomly divided into two groups with 64 patients in each group. The patients in the study group were treated by endoscopy and treated antibiotics to prevent infection, the control group received only endoscopic treatment. The levels of PCT and CRP were recorded at 1 day be- fore and 1 day and 7 days after the endoscopic treatment. The incidence of adverse reactions and the therapeutic effect were recorded. Results PCT and CRP levels in the two groups of patients before treatment were close（P〉0.05）; after treatment, the levels of PCT and CRP in study group were （0.97±0.23）ng/mL and （7.24±2.48）ng/mL, which were signifi cantly lower than those in the control group（P〈0.05）; the incidence 0f adverse reactions in the study group was lower than that in the control group（P〈O.05）. The therapeutic effect in the study group was significantly better than in the control group（P〈0.05）. Conclusion The use of antibiotics in patients with gastrointestinal bleeding after endoscopic treatment has significant effect, contribute to the rehabilitation of patients.

关 键 词：消化道出血 内镜治疗 降钙素原 C反应蛋白 

分 类 号：R57[医药卫生—消化系统]