缺氧诱导因子1α异常表达对肝细胞癌血管生成的调控作用  

Regulatory effect of abnormal expression of hypoxia- inducible factor- 1α on angiogenesis in hepatocellular carcinoma

作　　者：王理[1] 施维[1] 薛均[1] 潘璀然 姚敏[1] 姚登福[2] 

机构地区：[1]南通大学医学院,江苏南通226001 [2]南通大学附属医院,江苏南通226001

出　　处：《临床肝胆病杂志》2017年第2期369-374,共6页Journal of Clinical Hepatology

基　　金：江苏省"六大人才高峰"(2013-WSN-011);国家自然科学基金(81673241)

摘　　要：肝细胞癌是我国常见恶性肿瘤之一,伴有血供丰富,传统疗法易导致耐受,患者预后极差。肝组织缺氧诱导因子(HIF)1α与百余种下游靶基因的缺氧反应元件联合,参与血管新生、糖代谢等过程,从而抑制癌细胞分化和凋亡,促进癌细胞增殖。HIF-1α的高表达,以及对血管生成相关因子的调控,与肝癌患者放、化疗耐受,易浸润、转移及预后相关。综述了肝癌细胞HIF-1α异常表达对血管生成相关因子的调控作用和相互关系。Hepatocellular carcinoma（ HCC） is a common malignant tumor in China with abundant blood supply.Conventional therapies may easily cause tolerance and patients tend to have poor prognosis.Combined with the hypoxia response elements of over a hundred of downstream target genes,hypoxia- inducible factor- 1α（ HIF- 1α） in liver tissue participates in many processes including angiogenesis and glucose metabolism,inhibits the differentiation and apoptosis of tumor cells,and promotes the proliferation of tumor cells.High expression of HIF- 1α and its regulatory effect on angiogenesis- related factors are closely associated with patients＇ tolerance to radiotherapy and chemoradiotherapy,tumor invasion,metastasis,and prognosis.This article reviews the regulatory effect of abnormal expression of HIF- 1α in HCC cells on angiogenesis- related factors and their interrelation.

关 键 词：癌 肝细胞 缺氧诱导因子1 血管内皮生长因子类 血管生成素2 综述 

分 类 号：R735.7[医药卫生—肿瘤]