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机构地区:[1]广东药科大学中药学院,广州510006 [2]南方医科大学中医药学院,广州510515
出 处:《天然产物研究与开发》2017年第2期329-336,315,共9页Natural Product Research and Development
基 金:广东省科学技术重点项目(2011A030100010)
摘 要:通过高温加热试验、体外DPPH及酪氨酸酶抑制试验和人体皮肤保湿试验研究橄榄油、葡萄籽油、月见草油、火麻油、山茶油和茶树油的热稳定性、体外抗氧化及抑制酪氨酸酶能力和人体皮肤保湿能力,并进行综合评价打分。结果表明,橄榄油、月见草油较稳定(波长分别红移4、1 nm,吸光度增加了0.224、0.261),橄榄油、月见草油及葡萄籽油的体外抗氧化活性较好(IC50=298.40、281.53、277.27 mg/m L),25~325μg/m L的6种植物油对酪氨酸酶均无抑制作用(熊果苷的IC50=95.13μg/m L),茶树油和月见草油的人体皮肤保湿性能较好,不同含油量及环境湿度下均能显著提高皮肤水分含量。综合评价得分顺序依次为:月见草油>橄榄油>葡萄籽油>茶树油>山茶油>火麻油。In the present study,six vegetable oils,including olive oil,grape seed oil,evening primrose oil,sesame oil,camellia oil and tea tree oil,were used to synthetically assess some properties,such as thermal stability,in-vitro antioxidant,tyrosinase inhibition and human skin moisturizing ability. The results showed that olive oil and evening primrose oil were more stable than that of other oils under high temperature heating test. The maximum absorption wavelength only red-shifted 4 and 1 nm,respectively,and which absorbance increased by 0. 224 and 0. 261,respectively. Compared to other oils,olive oil,evening primrose oil and grape seed oil had better in-vitro antioxidant activity with IC50 values of298. 40,281. 53,277. 27 mg/mL,respectively. However,no tyrosinase inhibition was observed in six vegetable oils( 25-325 μg/mL) while IC50 of arbutin was 95. 13 μg/mL. In human skin moisturizing test,tea tree oil and evening primrose oil showed better activities than that of other oils,because they can significantly improve skin moisture content in different environment. In conclusion,the order of the six oils from optimal to worse were evening primrose oil,tea tree oil,grape seed oi,olive oil,camellia oil and sesame oil.
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