胃癌组织中PIK3CA基因突变频率及热点突变模式  

Investigation on mutation frequency of PIK3CA gene in gastric carcinoma and its hot spot mutation model

作　　者：邹伟[1] 张欢[1] 

机构地区：[1]惠州市中心人民医院,广东惠州516001

出　　处：《包头医学院学报》2017年第3期91-92,共2页Journal of Baotou Medical College

摘　　要：目的:研究胃癌组织中PIK3CA基因突变频率及热点突变模式。方法:抽取患者的组织DNA,检测胃癌PIK3CA基因突变。结果:160例胃癌标本中有48例出现了胃癌PIK3CA基因突变(30.00%),其中第9外显子有27例突变(56.25%),第20外显子和第7外显子分别有14例和7例突变(29.17%、14.58%)。结论:PIK3CA基因突变频率30.00%且热点突变集中。Objective：To explore the mutation frequency of PIK3CA gene in gastric carcinoma and its hot spot mutation model. Meth0ds：The mutation detection of DNA and PIK3CA gene was conducted, and the data was compared and analyzed. Results：There were 48 cases of mutation of PIK3CA gene presented among 160 cases, and the mutation rate was 30.00 % （48/160）. The mutation occurred in 27 cases, and the mutation cluster region was the ninth exon, which accounted for 56.25 % of the total sample. In addition, there were 14 cases and 7 cases of mutation in the twentieth and seventh exon, respectively, accounting for 29.17 % and 14.58 %. Conclusions：The mutation frequency of PIK3CA gene in gastric cancer was up to 30.00 % and the hot spots of mutation were concentrated.

关 键 词：胃癌组织 PIK3CA基因 频率 模式 

分 类 号：R735.2[医药卫生—肿瘤]