Rapid Microwave Assisted Synthesis and Antiproliferative Evaluation of Novel Steroidal Thiazole Derivatives  

作　　者：HUANG Yanmin ZHAO Dandan LIU Chang GAN Chunfang ZHAN Junyan LIN Qifu SHI Haixin CUI Jianguo 

机构地区：[1]College of Chemistry and Material Science, Guangxi Teachers Education University, Nanning 530001, P. R. China [2]Guangxi Colleges and University Key Laboratory of Beibu Gulf Oil and Natural Gas Resource Effectfve Utffizat~'on, Qizhou University, Qizhou 535011, P. R. China

出　　处：《Chemical Research in Chinese Universities》2017年第2期206-212,共7页高等学校化学研究（英文版）

摘　　要：Three series of novel steroidal thiazole derivatives were synthesized by microwave assisted one-potreaction from pregnenolone, testosterone and estrone, respectively. Their structures were characterized by IR, NMRand HRMS, and the antiproliferative activities of all the synthesized compounds against human cervical carcinoma（HeLa）, human liver carcinoma（HepG2）, human lung carcinoma（A549）, nasopharyngeal carcinoma（CNE2） andnormal kidney epithelial cells（HEK293T） were screened. Among the compounds, 1-estron-17＇-ylidene-2-[4＇-（p-bromophenyl）-2＇-thiazol]hydrazone（12） displayed distinct antiproliferative activity against all the tested cancercell lines and was almost inactive to normal kidney epithelial cells.

关 键 词：Microwave assisted synthesis PREGNENOLONE TESTOSTERONE ESTRONE Steroidal THIAZOLE DERIVATIVE 

分 类 号：O[理学]