PREGNENOLONE

作品数：6被引量：3H指数：1
导出分析报告
相关领域：医药卫生更多>>
相关作者：方芳李效军陈立功王晓季孙贤更多>>
相关机构：天津大学中国科学院大学复旦大学上海医学院哈尔滨医科大学更多>>
相关期刊：《Zoological Research》《Acta Pharmacologica Sinica》《Chemical Research in Chinese Universities》《Journal of Pharmaceutical Analysis》更多>>
相关基金：国家自然科学基金更多>>
-
在结果中检索

检索结果分析

结果分析中...
共 条 记 录，以下是1-6
全选清除导出
参考文献引证文献引用追踪
视图：
排序：
Activation of pregnane X receptor protects against cholestatic liver injury by inhibiting hepatocyte pyroptosis
《Acta Pharmacologica Sinica》2025年第1期147-158,共12页Hang-fei Liang Xiao Yang Hui-lin Li Xuan Li Jia-ning Tian Hai-guo Su Min Huang Jian-hong Fang Hui-chang Bi 
The work was supported by the National Key Research and Development Program of China(2022YFA1106700,2022YFA1104900);the National Natural Science Foundation of China(U23A20535,82025034,82274001,81973392,82204226);Guangdong Basic and Applied Basic Research Foundation(SL2022A04J01943);the Shenzhen Science and Technology Program(KQTD20190929174023858);the 111 project(B16047);the Key Laboratory Foundation of Guangdong Province(2017B030314030);the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2017BT01Y093).
Our previous study shows that activation of pregnane X receptor(PXR)exerts hepatoprotection against lithocholic acid(LCA)-induced cholestatic liver injury.In this study we investigated whether PXR activation could inh...
关键词：cholestatic liver injury pregnane X receptor pregnenolone 16a-carbonitrile PYROPTOSIS NLRP3 APAF-1 
Endogenous biosynthesis of docosahexaenoic acid(DHA)regulates fish oocyte maturation by promoting pregnenolone production被引量：2
《Zoological Research》2024年第1期176-188,共13页Yi Li Xuehui Li Ding Ye Ru Zhang Chengjie Liu Mudan He Houpeng Wang Wei Hu Yonghua Sun 
supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision Seed Design and Breeding,XDA24010108);National Natural Science Foundation of China(31972780&31721005);National Key R&D Program of China(2018YFA0801000);State Key Laboratory of Freshwater Ecology and Biotechnology(2019FBZ05)。
Omega-3 polyunsaturated fatty acids(n-3 PUFAs),particularly docosahexaenoic acid(22:6n-3,DHA),play crucial roles in the reproductive health of vertebrates,including humans.Nevertheless,the underlying mechanism related...
关键词：Docosahexaenoic acid Oocyte maturation Oocyte quality PREGNENOLONE MICROTUBULE 
Pregnenolone 16α-carbonitrile negatively regulates hippocampal cytochrome P450 enzymes and ameliorates phenytoin-induced hippocampal neurotoxicity
《Journal of Pharmaceutical Analysis》2023年第12期1510-1525,共16页Shuai Zhang Tingting Wang Ye Feng Fei Li Aijuan Qu Xiuchen Guan Hui Wang Dan Xu 
supported in part by grants from the National Natural Science Foundation of China(Grant Nos.:81973405,82122071,and 82030111)to Dan Xu;Hui Wang,the National Key R&D Program of China(Grant No.:2020YFA0803900)to Hui Wang;the Hubei Provincial Natural Science Foundation Outstanding Youth Found,China(Grant No.:2022CFA083).
The central nervous system is susceptible to the modulation of various neurophysiological processes by the cytochrome P450 enzyme(CYP),which plays a crucial role in the metabolism of neurosteroids.The antiepileptic dr...
关键词：Pregnenolone 16a-carbonitrile Pregnane X receptor Hippocampus Glucocorticoid receptor Phenytoin sodium NEUROTOXICITY 
Rapid Microwave Assisted Synthesis and Antiproliferative Evaluation of Novel Steroidal Thiazole Derivatives
《Chemical Research in Chinese Universities》2017年第2期206-212,共7页HUANG Yanmin ZHAO Dandan LIU Chang GAN Chunfang ZHAN Junyan LIN Qifu SHI Haixin CUI Jianguo 
Three series of novel steroidal thiazole derivatives were synthesized by microwave assisted one-potreaction from pregnenolone, testosterone and estrone, respectively. Their structures were characterized by IR, NMRand ...
关键词：Microwave assisted synthesis PREGNENOLONE TESTOSTERONE ESTRONE Steroidal THIAZOLE DERIVATIVE 
Effect of prototypical inducers on ligand activated nuclear receptor regulated drug disposition genes in rodent hepatic and intestinal cells
《Acta Pharmacologica Sinica》2010年第1期51-65,共15页Philip MARTIN Robert RILEY Paul THOMPSON Dominic WILLIAMS David BACK Andrew OWEN 
Aim： The aim of this study was to investigate the impact on expression of mRNA and protein by paradigm inducers/activators of nuclear receptors and their target genes in rat hepatic and intestinal cells. Furthermore,...
关键词：nuclear receptors hepatic cells intestinal cells prototypical inducers RODENTS DEXAMETHASONE pregnenolone 16α carbonitrile cytochrome P450 pregnane X receptor constituitive androstane receptor 
SYNTHESIS OF FINASTERIDE被引量：1
《Transactions of Tianjin University》2001年第4期286-289,共4页李效军 方芳 王晓季 陈立功 
As a kind of substrate competition type 5α reductase inhibitor,finasteride is a promising medicine used in the clinical treatment of benign prostatic hyperplasia (BPH).In this paper,a new route for the synthesis of...
关键词：FINASTERIDE SYNTHESIS PREGNENOLONE 
全选清除导出
共1页<1>
检索报告 对象比较 聚类工具 使用帮助 返回顶部