体细胞突变对结直肠癌转移方式的影响  

Effect of Somatic Mutation on Metastatic Patterns of Colorectal Cancer

作　　者：吴源兵[1] 王祥财[2] 

机构地区：[1]赣南医学院,江西赣州341000 [2]赣南医学院第一附属医院肿瘤科,江西赣州341000

出　　处：《赣南医学院学报》2017年第1期131-134,162,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：体细胞突变是指基因突变最初发生在体细胞上,不能遗传给下一代。40%的结直肠癌相关基因会发生体细胞突变,了解体细胞突变与结直肠癌(colorectal cancer,CRC)转移方式的关系非常重要,因为体细胞突变与疾病预后密切相关。此外,了解具体的转移方式将有助于临床医师评估结直肠患者的症状,指导临床治疗。在此,我们主要就体细胞中KRAS,BRAF,PIK3CA,NRAS,TP53基因突变对结直肠癌转移方式的影响进行综述。Somatic mutations refers to gene mutations occuring in somatic cell and these mutations cannot be inherited to the next generation. Somatic mutations were detected in 40% of CRC-related genes. It is very significant to understand the relationship between somatic mutation and metastatic patterns of colorectal cancer, because somatic mutation is closely related to the prognosis of disease. In addition, an understanding of specific metastatic pattern may help to inform physicians＂ assessment of symptoms and guide clinical treatment in patients with mCRC. The paper has mainly reviewed the effect of KRAS, BRAF, PIK3CA, NRAS and TP53 gene mutation on cotorectal cancer metastasis.

关 键 词：体细胞突变 结直肠癌 转移 KRAS BRAF PIK3CA 

分 类 号：R735.37[医药卫生—肿瘤]