2型糖尿病患者的总能量消耗量及其与氧化应激的相关性研究  

Total energy expenditure and its association with oxidative stress in patients with type 2 diabetes

作　　者：周倩[1] 何俊卿[1] 曾晶[2] 蒋卓勤[1] ZHOU Qian HE Jun-qing ZENG Jing JIANG Zhuo-qin(School of Public Health, Sun Yat-sen University, Guangzhou 510080, China Guangdong Provincial Corps Hospital of Chinese People＇s Armed Police Forces)

机构地区：[1]中山大学公共卫生学院,广东广州510080 [2]武警广东总队医院

出　　处：《华南预防医学》2017年第2期112-116,共5页South China Journal of Preventive Medicine

摘　　要：目的研究2型糖尿病患者的总能量消耗量(TEE)及其与患者体内氧化应激水平的相关性。方法以广州市某三甲医院内分泌门诊30~70岁2型糖尿病患者为调查对象,对其24 h体力活动情况进行调查,应用要因加算法求出TEE,采用ELISA法检测尿液中8-羟基脱氧鸟苷(8-OHdG)和8-异前列腺素F2α(8-iso-PGF2α)的浓度以评价调查对象的氧化应激水平,最终采用相关分析及多重线性回归分析研究氧化应激指标与TEE的相关性。结果共调查2型糖尿病患者222例,女性占47.7%(106/222),30~49岁者占48.6%(103/222),广东籍占59.0%(131/222)。男、女性患者的休息和极轻活动之和分别占总活动时间的86.6%、83.4%;男性在轻体力活动上分配的时间少于女性(P<0.01),极轻活动中的坐姿活动多于女性(P<0.01)。男、女性患者的TEE分别为160.4、153.3 kJ/(kg·d),重体力活动水平下各年龄组的TEE均高于相应的RNI值。Pearson相关性分析结果显示,尿中8-OHdG及8-iso-PGF2α均与TEE呈正相关(P<0.05或P<0.01);多重线性回归分析结果显示,8-OHdG及8-iso-PGF2α浓度的影响因素均包括TEE(均P<0.01)。结论重体力活动的2型糖尿病患者的TEE高于其RNI值,TEE可能影响患者尿中8-OHdG及8-iso-PGF2α浓度,有可能增加其体内氧化应激水平。Objective To assess the level of total energy expenditure （TEE） and its association with oxidative stress in patients with type 2 diabetes. Methods Patients aged 30 -70 years with type 2 diabetes were selected from a general hospital in Guangzhou as the subjects. Their information about 24 - hour physical activities were collected to calculate the TEE using the factorial calculation. ELISA was used to detect the concentrations of 8-OHdG and 8-iso-PGF2α in urine to evaluate the level of oxidative stress. Pearson correlation coefficient and multiple linear regression were used to analyze the correlation between the oxidative stress and TEE. Results A total of 222 patients were finally involved in this study. Of them, 47.7% （ 106/222 ） were females 48.6% （ 103/222 ） were aged 30 - 49 years, and 59.0% （131/222） were from Guangdong Province. Rest and very-low activity were accounted for 86.6% and 83.4% of the total time in males and females, respectively. Compared with females, males spent less time on light activity （ P 〈0. 01 ）, while more time on sitting （ P 〈 0. 01 ）. TEEs were 160.4 k J/（ kg · d） for males and 153.3 kJ/（ kg · d） for females, and higher in each age group than the corresponding reference nutrient intakes （RNIs） at heavy physical activity level. Pearson correlation analysis showed that the concentrations of 8-OHdG and 8-iso-PGF2α were positively correlated with TEE （P 〈 0. 05 and P 〈 0.01, respectively）. Multiple linear regression showed that TEE was an influencing factor for the concentration of 8- OHdG and 8-iso-PGF2α （ both P 〈 0.01 ）. Conclusion TEEs of patients with type 2 diabete mellitus and heavy physical activity were higher than RNI, and may affect the concentrations of 8-OHdG and 8-iso- PGF2α in urine and increase the level of oxidative stress.

关 键 词：糖尿病 2型 能量代谢 氧化性应激 

分 类 号：R151.4[医药卫生—营养与食品卫生学]