原发性肝癌PD-L1和PD-L2表达  

Expression of PD-L1 and PD-L2 in primary hepatocellular carcinoma

作　　者：王征帆[1] 王豪勋[2] 李楠[2] 赵晓静[2] 张中冕[2] 陈香宇[3] 周士霞[2] 张玲[1] 段芳龄[2] 马军[2] 

机构地区：[1]郑州大学附属肿瘤医院(河南省肿瘤医院)检验科,郑州450008 [2]郑州大学第二附属医院 [3]郑州大学第一附属医院

出　　处：《医药论坛杂志》2017年第2期14-15,共2页Journal of Medical Forum

基　　金：河南省医学科技攻关计划项目;教育部留学人员科技活动项目择优资助([2006]321)

摘　　要：目的研究原发性肝癌和癌旁组织中PD-L1和PD-L2的表达。方法采用组织芯片和免疫组化方法,检测40例HCC、36例癌旁组织PD-L1和PD-L2表达,其中36例HCC和27例癌旁组织有病理临床资料。结果 PD-L1在HCC和癌旁组织中的表达率分别为50%和77.8%(P<0.05),PD-L2的表达率分别为70%和80.6%(P>0.05),未发现PD-L1或PD-L2的表达和年龄、性别、HBV的感染状态、转移等有相关性。配对分析显示PD-L1和PD-L2在癌旁组织的表达有同样的趋势,而HCC中PD-L2表达高于PD-L1。结论HCC中有较高的PD-L1和PD-L2表达率,PD-L1可能在肝癌发病早期起重要作用。Objective To explore the expressions of PD - L1 and PD - L2 in hepatocellular carcinoma （HCC）. Meth- ods Immunohistochemistry was used to detect expressions of PD - L1 and PD - 122 in tissue array of HCC specimens （40 HCC and 36 para - cancerous specimens）. Results Expression of PD - L1 was found in 50% HCC and 77.8% para - cancerous tissues respectively （ P 〈 0. 05 ）. No difference was found for PD - L2 expression between HCC and para - cancerous tissues. Expressions of these two proteins had no relationship with patho - clinical features of HCC. Paired analysis showed expression of PD - L1 consistent with PD - L2 in para - cancerous tissues, but not in HCC. Conclusion High expressions of PD- L1 and PD- L2 exist in HCC. PD- L1 might be involved in ear/y stage of HCC.

关 键 词：原发性肝癌 PD-L1 PD-L2 

分 类 号：R735.7[医药卫生—肿瘤]