基于AngⅡ、ApoE表达探讨补肾中药复方首参颗粒对颈动脉粥样硬化患者的影响  

Effect of Chinese herbal formula for reinforcing kidney Shoushen Granules for the patients with carotid atherosclerosis based on the expression of AngⅡ and ApoE

作　　者：申定珠[1] 陈川[1] 邢三丽[1] 楼丹飞[2] 沈睿[3] 吴蓓玲[1] 迟惠英[1] 陈久林[1] 

机构地区：[1]上海市中医老年医学研究所,上海200031 [2]上海中医药大学附属市中医医院老年病科,上海200071 [3]上海中医药大学附属市中医医院功能科,上海200071

出　　处：《中国医药导报》2017年第10期96-99,108,共5页China Medical Herald

基　　金：国家自然科学基金资助项目(81373706);上海市自然科学基金项目(16ZR1433900);上海市卫计委科研项目(20114047;201640217)

摘　　要：目的基于Ang Ⅱ、ApoE的表达观察补肾中药复方首参颗粒对颈动脉粥样硬化患者的影响。方法选取2011年6月~2012年1月上海中医药大学附属市中医医院老年病科颈动脉粥样硬化患者80例为研究对象,采用区组随机化方法将其分为观察组(40例)和对照组(40例)。两组分别予以首参颗粒、普伐他汀口服治疗,疗程6个月。于治疗前、治疗后分别采用酶联免疫吸附测定(ELISA)法检测患者血清AngⅡ、ApoE表达。结果治疗后6个月,观察组AngⅡ表达较治疗前显著降低(P<0.01),与对照组同期比较差异无统计学意义(P>0.05);观察组ApoE表达较治疗前明显上升(P<0.01),与对照组同期比较差异无统计学意义(P>0.05)。结论首参颗粒可能通过调控AngⅡ、ApoE的表达进而实现对动脉粥样硬化的多靶点干预。Objective To observe the effect of Chinese herbal formula for reinforcing kidney Shoushen Granules for the patients with carotid atherosclerosis based on the expression of Ang Ⅱ and ApoE. Methods Eighty cases of patients with carotid atherosclerosis admitted to Department of Geriatrics, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine from June 2011 to January 2012 were selected as research objects, and they were divided into observation group （40 cases） and control group （40 cases） by method of block randomization. They were treated with Shoushen Granules or Pravastatin orally respectively for 6 months. Before and after treatment, the expression of Ang Ⅱ and ApoE in serum was detected by enzyme-linked immunosorbent assay （ELISA） method respectively. Results Compared with before treatment, the expression of Ang Ⅱ in the observation group after treatment was significantly decreased （P〈 0.01）, which had no statistically significant differences compared with those of control group at the same time （P 〉 0.05）. While the expression of ApoE in the observation group after treatment was significantly improved （P 〈 0.01）, which had no statistically significant differences compared with those of control group at the same time （P 〉 0.05）. Conclusion Shoushen Granules achieve multiple target intervention of atherosclerosis may be through regulating the expression of Ang Ⅲ and ApoE.

关 键 词：颈动脉粥样硬化 首参颗粒 AngⅡ APO E 

分 类 号：R743[医药卫生—神经病学与精神病学]